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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to very faintly yellow
溶解度
DMSO: >15 mg/mL
起源
Allergan
儲存溫度
2-8°C
SMILES 字串
S1CCC(c2c1ccc(c2)C#Cc3ncc(cc3)C(=O)OCC)(C)C
InChI
1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
InChI 密鑰
OGQICQVSFDPSEI-UHFFFAOYSA-N
生化／生理作用
Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene.
Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. It is a prodrug of tazarotenic acid, which specifically activates RARb and RARg, only weakly activates RARa, and is inactive at retinoid X receptors (RXRs). In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.
特點和優勢
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Allergan. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Warning
危險聲明
危險分類
Repr. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Yu-Chen Huang et al.
Lasers in surgery and medicine, 45(2), 102-107 (2013-02-21)
Nail psoriasis is difficult to treat. The efficacy of pulsed dye laser (PDL) therapy for nail psoriasis has been reported in non-placebo controlled studies. To evaluate the efficacy and safety of PDL with topical retinoid in the treatment of nail
Jorge Viera-Vera et al.
Biomolecules, 9(12) (2019-12-19)
Almost every organism has the ability of repairing damaged tissues or replacing lost and worn out body parts, nevertheless the degree of the response substantially differs between each species. Adult sea cucumbers from the Holothuria glaberrima species can eviscerate various
L Guenther
Journal of the American Academy of Dermatology, 43(2 Pt 3), S36-S42 (2000-07-18)
In the hope of increasing efficacy and improving safety, several combination regimens involving tazarotene gel have been explored for the treatment of plaque psoriasis. A number of large-scale studies have shown that the adjunctive use of a mid-potency or high-potency
Essam Bakr Abd El-Aal et al.
The Journal of dermatological treatment, 30(3), 277-282 (2018-08-08)
Onychomycosis is a chronic fungal infection of the nails, and the treatment has been proven to be a challenge to healthcare professionals. To evaluate the efficacy of fractional carbon dioxide laser-assisted delivery of topical tazarotene versus topical tioconazole in the
A Menter
Journal of the American Academy of Dermatology, 43(2 Pt 3), S31-S35 (2000-07-18)
The pharmacokinetic profile of tazarotene helps to ensure that systemic exposure to the drug and its metabolites is minimal. First, percutaneous penetration is limited, with less than 6% of the applied drug being absorbed into the bloodstream. Second, tazarotene is
商品
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