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形狀
lyophilized (white powder to sticky mass to hard pellet)
品質等級
比活性
≥9 units/μg protein (cyclic-AMP is not required for this activity)
分子量
40,862 Da
儲存溫度
−20°C
一般說明
蛋白激酶一种酶由两个亚单位（催化亚单位和调节亚单位）组成。催化亚基在环磷酸腺苷存在下作为单体存在，分子量为40,862 Da。
應用
牛心脏蛋白激酶A （PKA）催化亚单位已用于
- 研究PKA介导的IRK1（内向整流K+）通道抑制
- 体外 PKA磷酸化测定
- 体外亲和结合测定
- 研究PKA对功能活动运动神经元吸气驱动电流的影响
生化／生理作用
蛋白激酶A (PKA)控制Hedgehog信号转导，并参与增殖和命运决定。它可以使几种神经递质受体、转录因子和多种细胞内信号通路的成分磷酸化。
蛋白激酶A催化末端磷酸从ATP转移到存在于各种蛋白质上的苏氨酸或丝氨酸残基。这种蛋白质在没有环磷酸腺苷的情况下是无活性的，环磷酸腺苷是催化亚基和调节亚基结合在一起的地方。存在cAMP时，调节亚单位与cAMP结合并释放催化亚单位。
包裝
包装规格基于磷酸化单位
單位定義
在 pH 6.5、30°C，一单位每分钟可将 1.0 pmol磷酸盐从 ATP转化为水解和部分去磷酸化的酪蛋白，并可通过测量ADP产量进行测定。
外觀
冻干粉，含蔗糖和磷酸缓冲盐作为稳定剂。
準備報告
由蛋白激酶 A (P 5511) 制成
免責聲明
Please note that the pack size has been changed to align with the unit definition, while the number of phosphorylating units remain the same as before.
抑制劑
产品编号
说明
价格
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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