跳转至内容
Merck
所有图片(1)

文件

P0300

Sigma-Aldrich

蛋白激酶抑制剂 来源于兔

≥85% (HPLC)

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C94H148N32O31
CAS号:
99534-03-9
分子量:
2222.38
MDL號碼:
MFCD00133989
分類程式碼代碼:
12352200
PubChem物質ID:
24898093

生物源

rabbit

化驗

≥85% (HPLC)

形狀

powder

分子量

2.2 kDa

成份

Peptide content, ≥70%

溶解度

water: 1 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

CCC(C)C(NC(=O)C(C)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(CO)NC(=O)C(C)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(NC(=O)C(N)C(C)O)C(C)O)C(C)CC)C(C)O)C(=O)NC(Cc3cnc[nH]3)C(=O)NC(CC(O)=O)C(O)=O

InChI

1S/C94H148N32O31/c1-11-42(3)70(124-85(150)58(31-50-19-14-13-15-20-50)117-84(149)61(35-67(135)136)116-74(139)44(5)110-81(146)57(32-51-24-26-53(131)27-25-51)119-90(155)73(49(10)130)126-86(151)69(96)47(8)128)88(153)112-45(6)75(140)122-63(40-127)77(142)107-38-65(133)114-55(22-17-29-105-93(99)100)80(145)125-72(48(9)129)87(152)108-39-66(134)113-54(21-16-28-104-92(97)98)78(143)115-56(23-18-30-106-94(101)102)79(144)118-60(34-64(95)132)82(147)111-46(7)76(141)123-71(43(4)12-2)89(154)120-59(33-52-37-103-41-109-52)83(148)121-62(91(156)157)36-68(137)138/h13-15,19-20,24-27,37,41-49,54-63,69-73,127-131H,11-12,16-18,21-23,28-36,38-40,96H2,1-10H3,(H2,95,132)(H,103,109)(H,107,142)(H,108,152)(H,110,146)(H,111,147)(H,112,153)(H,113,134)(H,114,133)(H,115,143)(H,116,139)(H,117,149)(H,118,144)(H,119,155)(H,120,154)(H,121,148)(H,122,140)(H,123,141)(H,124,150)(H,125,145)(H,126,151)(H,135,136)(H,137,138)(H,156,157)(H4,97,98,104)(H4,99,100,105)(H4,101,102,106)

InChI 密鑰

AXOXZJJMUVSZQY-UHFFFAOYSA-N

正在寻找类似产品? 访问 产品对比指南

Amino Acid Sequence

Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp

生化／生理作用

cAMP 依赖性蛋白激酶抑制剂
这些蛋白可与 cAMP 依赖性蛋白激酶的催化亚基结合，从而取代调节亚基并抑制磷酸化活性。调节亚基的 cAMP 结合能力得以增强。许多其他蛋白也表现出这种增强能力 (Brostrom, C.O. and Kon, C., Anal. Biochem., 58, 459 [1974])。

特點和優勢

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

J W Kasckow et al.
Synapse (New York, N.Y.), 18(4), 354-358 (1994-12-01)
Interleukin-1 (IL1) is a key messenger implicated in endocrine and immune systems that interact to mediate the stress response. Corticotropin-releasing factor (CRF) secretion and synthesis in the NPLC-KC human hepatoma cell line has been shown to respond to IL1 stimulation.
T Miralem et al.
The Journal of biological chemistry, 271(29), 17100-17106 (1996-07-19)
Heparin suppresses mitogenic responses in renal mesangial cells, and when quiescent mesangial cells are stimulated with serum, heparin blocks the induction of c-fos seen at 15 min. Because heparin is taken up by cells over a much longer time course
L Kapural et al.
Biochimica et biophysica acta, 1355(3), 331-342 (1997-03-01)
We examined the effects of platelet activators and inhibitors of platelet function on the voltage-gated delayed rectifier K+ current of human megakaryocytes. We found that both the activators such as thrombin, the thrombin receptor peptide (TRP42-47) and ADP and the
Z Wang et al.
The Journal of biological chemistry, 273(1), 73-79 (1998-02-07)
Cadmium is mitogenic under some circumstances and has been shown to cause accumulation of transcripts for several proto-oncogenes in a variety of cells, but the mechanism(s) remain to be delineated. Here we show that CdCl2 causes an increase in c-fos
Li Chen et al.
Food chemistry, 293, 537-544 (2019-06-04)
To verify the effect of protein phosphorylation on glycolysis and elucidate the regulatory mechanism from the perspective of enzyme activity, ovine muscle was treated with a kinase inhibitor, dimethyl sulfoxide, or a phosphatase inhibitor and the activities of glycogen phosphorylase
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门