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Merck
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文件

I2764

Sigma-Aldrich

ML-7

powder

别名:

1-（5-碘萘-1-磺酰基）-1H - 六氢-1，4-二氮杂卓 盐酸盐

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About This Item

经验公式（希尔记法）:
C15H17IN2O2S · HCl
CAS号:
110448-33-4
分子量:
452.74
MDL號碼:
MFCD00065524
分類程式碼代碼:
12352200
PubChem物質ID:
24278490
NACRES:
NA.77

化驗

≥98% (TLC)

形狀

powder

顏色

white

溶解度

ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow

儲存溫度

−20°C

SMILES 字串

Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

InChI 密鑰

KDDALCDYHZIZMH-UHFFFAOYSA-N

基因資訊

human ... MYLK(4638) , MYLK2(85366)

應用

ML-7在各种实验中用作肌球蛋白轻链激酶(MLCK)抑制剂。

生化／生理作用

选择性肌球蛋白轻链激酶抑制剂。

特點和優勢

《受体分类和信号转导》手册的 Ca/CaMKs 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
Antoine TE and Shukla D
Antiviral Therapy, 19, 15-29 (2014)
Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin?Analysis of patient mutations
Klaavuniemi T and Ylanne J
Experimental Cell Research, 312(8), 1299-1311 (2006)
Kristopher E Kubow et al.
Scientific reports, 7(1), 14380-14380 (2017-11-01)
Contact guidance-cell polarization by anisotropic substrate features-is integral to numerous physiological processes; however the complexities of its regulation are only beginning to be discovered. In particular, cells polarize to anisotropic features under non-muscle myosin II (MII) inhibition, despite MII ordinarily
Sylvain Recoquillon et al.
Scientific reports, 7(1), 13664-13664 (2017-10-24)
Obstructive sleep apnea is characterized by intermittent hypoxia (IH) which alters endothelial function, induces inflammation and accelerates atherosclerosis-induced cardiovascular diseases. The non-muscular myosin light chain kinase (nmMLCK) isoform contributes to endothelial cell-cell junction opening. Deletion of nmMLCK protects mice from
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