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产品名称
菲律宾菌素复合体 来源于菲律宾链霉菌, ≥70% (UV)
生物来源
Streptomyces sp. (Streptomyces filipinensis)
质量水平
方案
≥70% (UV)
表单
powder
溶解性
methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow
抗生素抗菌谱
fungi
作用机制
cell membrane | interferes
储存温度
−20°C
InChI
1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
InChI key
IMQSIXYSKPIGPD-YQRUMEKGSA-N
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一般描述
化学结构：大环内酯
应用
来自非律平链霉菌的非律平复合物已用作检测细胞中游离胆固醇的荧光探针。
生化/生理作用
菲律平是一种多烯大环内酯类抗生素和抗真菌药。抗真菌作用的机制尚不清楚，但可能是由于通过与膜固醇结合而改变了膜的通透性和相关功能。 非律平与膜固醇（如胆固醇）结合，抑制朊蛋白（PrP）的内吞作用，并使 PrP 从质膜释放。
菲律平是一种多烯大环内酯类抗生素和抗真菌药。抗真菌作用的机理尚不清楚，但可能是由于膜通透性改变所致。 非律平以形成膜孔的方向与含胆固醇的模型结晶相脂质双层结合，并与具有或没有胆固醇的液相双层结合。它既抑制蛋白（PrP）的内吞作用，又导致 PrP 从质膜释放。
其他说明
非律平包含 8 个异构体成分，其中非律平 III 是主要成分。
相关产品
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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