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B7148

Sigma-Aldrich

丁螺环酮盐酸盐 盐酸盐

≥99% (TLC), powder, 5-HT1A serotonin receptor agonist

别名:

N-[4-[4-(2-嘧啶基)-1-哌嗪基] 丁基]-8-氮杂螺[4.5]癸烷-7,9-二酮 盐酸盐

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About This Item

经验公式（希尔记法）:
C21H31N5O2 · HCl
CAS号:
33386-08-2
分子量:
421.96
EC號碼:
251-489-4
MDL號碼:
MFCD00078569
分類程式碼代碼:
12352200
PubChem物質ID:
24278079
NACRES:
NA.77

产品名称

丁螺环酮盐酸盐 盐酸盐,

形狀

powder

品質等級

100

起源

Bristol-Myers Squibb

儲存溫度

2-8°C

SMILES 字串

Cl[H].O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4

InChI

1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

InChI 密鑰

RICLFGYGYQXUFH-UHFFFAOYSA-N

基因資訊

human ... HTR1A(3350)

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相关类别

生化／生理作用

5-HT 1A 血清素受体激动剂；抗焦虑药。

特點和優勢

该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是神经科学研究的特色产品。 点击此处 ，发现更多特色神经科学产品。访问sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子的信息。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCK4551
BCCG0755
BCCC9648
BCBZ3793
BCBW1483

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G Tunnicliff
Pharmacology & toxicology, 69(3), 149-156 (1991-09-01)
Buspirone has been available in the United States for over four years for the treatment of anxiety. It was anticipated this drug would offer certain advantages over the established benzodiazepines. In contrast to diazepam, early studies found no evidence for
E Meller et al.
Molecular pharmacology, 37(2), 231-237 (1990-02-01)
The irreversible receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was used to determine the relationship between receptor occupancy and response at central 5-hydroxytryptamine1A (5-HT1A) serotonin receptors mediating the inhibition of serotonin synthesis in rat cortex and hippocampus. Rats were treated with vehicle or
D F Avgustinovich et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 98(6), 693-705 (2012-09-28)
The influence of acute and chronic (14 days) buspirone administration (1 mg/kg, intraperitoneally) on the behavior of C57BL/6J female mice, being in social discomfort, were studied. The conditions of social discomfort include the permanent habitation of females in the cage
Hedayat Nazari et al.
Archives of gynecology and obstetrics, 287(3), 469-472 (2012-10-18)
The premenstrual syndrome (PMS), which causes emotional and physical symptoms, is a common problem in many women in their reproductive age. Many approaches to PMS with controversial results are available. The present study was performed to compare fluoxetine and buspirone
Jan Tack et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 10(11), 1239-1245 (2012-07-21)
Impaired accommodation and hypersensitivity to gastric distention are believed to be involved in the development of functional dyspepsia (FD). Buspirone, a 5-hydroxytryptamine 1A receptor agonist, relaxes the proximal stomach in healthy individuals. We studied the effects of buspirone on symptoms
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