H140
(R)-(+)-8-Hydroxy-DPAT hydrobromide
≥98% (HPLC), solid
别名:
(R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
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所有图片(1)
About This Item
经验公式（希尔记法）:
C16H25NO · HBr
CAS号:
分子量:
328.29
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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化驗
≥98% (HPLC)
形狀
solid
光學活性
[α]25/D +68.2°, c = 1 in methanol(lit.)
儲存條件
desiccated
protect from light
顏色
white to off-white
溶解度
H2O: >10 mg/mL at ±60 °C (with sonication)
SMILES 字串
Br.CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
InChI
1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1
InChI 密鑰
BATPBOZTBNNDLN-PFEQFJNWSA-N
基因資訊
human ... HTR1A(3350)
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應用
(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:
- in mice to test the activity of the serotonin receptor
- to test its effect on zebrafish melanocyte migration and survival
- to stimulate hippocampal neurons
生化／生理作用
(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.
(R)-(+)-8-Hydroxy-DPAT is a full 5-HT1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Jan Brosda et al.
ACS chemical neuroscience, 6(7), 1176-1185 (2015-03-18)
Brain serotonin (5-HT) is involved in the control of food intake. The ingestive effects of 5-HT are mediated by various receptor subtypes, among others the 5-HT1A receptor. While the involvement of presynaptic 5-HT1A receptors is regarded as certain, the role
Mice do not habituate to metabolism cage housing-a three week study of male BALB/c mice
Kalliokoski O, et al.
PLoS ONE, 8(3), 1176-1185 (2013)
Masatoshi Nagano et al.
Scientific reports, 8(1), 13675-13675 (2018-09-14)
Disturbance of neurotransmitters and neuromodulators is thought to underlie the pathophysiology of autism spectrum disorder (ASD). Studies of 15q dup mouse models of ASD with human 15q11-13 duplication have revealed that restoring serotonin (5-HT) levels can partially reverse ASD-related symptoms
Sietse F de Boer et al.
European journal of pharmacology, 526(1-3), 125-139 (2005-11-29)
More than any other brain neurotransmitter system, the indolamine serotonin (5-HT) has been linked to aggression in a wide and diverse range of species, including humans. The nature of this linkage, however, is not simple and it has proven difficult
Dasiel O Borroto-Escuela et al.
Biochemical and biophysical research communications, 441(2), 387-392 (2013-10-26)
New findings show that neurotrophic and antidepressant effects of 5-HT in brain can, in part, be mediated by activation of the 5-HT1A receptor protomer in the hippocampal and raphe FGFR1-5-HT1A heteroreceptor complexes enhancing the FGFR1 signaling. The dynamic agonist modulation
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