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Merck
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E-901

Supelco

艾司唑仑标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C16H11ClN4
CAS号:
29975-16-4
分子量:
294.74
EC號碼:
200-659-6
分類程式碼代碼:
41116107
NACRES:
NA.24

等級

certified reference material

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

濃度

1.0 mg/mL in methanol

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing

格式

single component solution

儲存溫度

−20°C

SMILES 字串

Clc1ccc-2c(c1)C(=NCc3nncn-23)c4ccccc4

InChI

1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2

InChI 密鑰

CDCHDCWJMGXXRH-UHFFFAOYSA-N

基因資訊

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

相关类别

一般說明

CRM质量级别的Snap-N-Spike®溶液适合用作从法医分析和临床毒理学研究到尿液药物检测的各种LC/MS或GC/MS应用的校准品或对照品的起始材料。艾司唑仑是一种苯二氮卓类药物，可用于失眠症的短期治疗。艾司唑仑以ProSom或悠乐丁等商品名出售，经常被娱乐性滥用以达到高剂量或违反医生的建议而长期使用。

應用


  • Estazolam in environmental trace analysis: A study employing ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) detailed the detection of Estazolam among other psychotropic medications in environmental samples, underscoring the method′s precision and application in monitoring environmental contamination by pharmaceutical residues (Wang et al., 2024).

  • Estazolam and insomnia post-coronavirus disease: Research analyzed insomnia prevalence among COVID-19 survivors, identifying Estazolam as part of the therapeutic regimen. This study highlights the ongoing relevance of Estazolam in addressing sleep disorders associated with long-term recovery from significant health events (Lu et al., 2024).

  • Comparative analysis of Estazolam for post-stroke insomnia: A network meta-analysis compared various treatments for post-stroke insomnia, including Estazolam, providing insights into its effectiveness relative to other therapeutic options. This study contributes to understanding optimal treatment strategies for insomnia in post-stroke patients (Song et al., 2023).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

分析证书(COA)

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Masatomo Miura et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 18(5), 525-528 (2002-05-31)
A high-performance liquid chromatography (HPLC) assay was developed for the determination of estazolam in human plasma. Estazolam and alprazolam as an internal standard were detected by ultraviolet absorbance at 240 nm. Estazolam in plasma was extracted by a rapid and
Yuan Tian et al.
Journal of pharmaceutical and biomedical analysis, 47(4-5), 899-906 (2008-05-13)
A simple, rapid, sensitive and selective liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the quantification of rupatadine in human plasma using estazolam as internal standard (IS). Following liquid-liquid extraction, the analytes were separated using a mobile
H Inoue et al.
Forensic science international, 113(1-3), 367-373 (2000-09-09)
Benzodiazepines are one of the most widely prescribed drugs for the treatment of a wide spectrum of clinical disorders. They are used as anticonvulsants, anxiolytics, hypnotics or muscle relaxants with different duration of action. In this paper, a simple and
M Miura et al.
Xenobiotica; the fate of foreign compounds in biological systems, 35(5), 455-465 (2005-07-14)
To predict drug interactions with estazolam, the biotransformation of estazolam to its major hydoxylated metabolite, 4-hydroxyestazolam was studied in vitro using pooled human liver microsomes and individual expressed human cytochrome P450 (CYP) enzymes. Estazolam was metabolized to 4-hydroxyestazolam according to
Yahdiana Harahap et al.
Arzneimittel-Forschung, 58(10), 501-504 (2008-11-26)
To compare the bioavailability of two estazolam (CAS 29975-16-4) tablet formulations (Estalin 2 mg tablets as test formulation and 2 mg tablets of the originator product as reference formulation). The study was conducted according to an open label, randomized two-way
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