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A-903

Supelco

阿普唑仑标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C17H13ClN4
CAS号:
28981-97-7
分子量:
308.76
EC號碼:
200-659-6
MDL號碼:
MFCD00078881
分類程式碼代碼:
41116107
PubChem物質ID:
329771027
NACRES:
NA.24

等級

certified reference material

品質等級

300

形狀

liquid

特點

SNAP-N-SPIKE®, SNAP-N-SHOOT®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

濃度

1.0 mg/mL in methanol

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing

形式

single component solution

儲存溫度

−20°C

SMILES 字串

Cc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12

InChI

1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3

InChI 密鑰

VREFGVBLTWBCJP-UHFFFAOYSA-N

基因資訊

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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一般說明

阿普唑仑是一种苯二氮卓类药物，可用于治疗焦虑症和恐慌症，包括广泛性或社交焦虑症。此认证的参考标准品通过LC/MS或GC/MS，可用于从法医分析和临床毒理学到尿液药物测试方面的各种应用中。阿普唑仑以商品名Xanax出售®。

應用


  • 阿普唑仑固体脂质纳米粒用于缓释：开发基于Compritol的阿普唑仑固体脂质纳米粒，为苯二氮䓬生物化学带来新的缓释制剂方法。该方法可保证药物控释并提升生物利用度，对抗焦虑物质药代学的改进有重要意义(Rao et al., 2022)。

  • 生物样本中阿普唑仑的提取：采用纳米石墨烯（α-吡啶胺接枝）进行阿普唑仑的分散固相萃取，有重要的法医和临床毒理学意义。该方法提高复杂生物基质中苯二氮䓬检测的精密度，对神经药理研究极具意义(Parsayi Arvand et al., 2023)。

  • 药物滥用分析中的拉曼光谱技术：利用便携式拉曼光谱技术检测药物滥用（包括阿普唑仑）。本文开发了阿普唑仑的快速无损检测方法，促进法庭科学发展(Santos et al., 2022)。

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Xanax is a registered trademark of Pharmacia & Upjohn Company

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訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes,Central nervous system

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

分析证书(COA)

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Dean T Acheson et al.
Human psychopharmacology, 27(4), 419-427 (2012-07-12)
Heightened anticipation of future events has been characterized as a feature of certain anxiety disorders. In functional magnetic resonance imaging studies, anticipation of fearful/threatening images has been shown to robustly activate the insular cortex and amygdala in healthy subjects, in
J M Jonas et al.
The Journal of clinical psychiatry, 54 Suppl, 25-45 (1993-10-01)
A review of the worldwide published literature was conducted to assess the efficacy and safety of alprazolam for the treatment of anxiety disorders, panic disorder, and depression in comparison with those of other active drugs (including other benzodiazepines and antidepressant
J O Cole et al.
The Journal of clinical psychiatry, 54 Suppl, 49-61 (1993-10-01)
A review of the published case reports of adverse behavioral episodes or unexpected psychopathology in patients taking benzodiazepines was undertaken in an attempt to determine if these adverse or unexpected events are more likely to occur with alprazolam when compared
E M Sellers et al.
The Journal of clinical psychiatry, 54 Suppl, 64-75 (1993-10-01)
The incidence of nonmedical use of alprazolam is very low relative to its widespread legitimate medical use; in fact, given the millions of patients who have received this medication, the incidence is remarkably small. In particular, among patients with anxiety
Gary G Kay et al.
Postgraduate medicine, 124(3), 7-15 (2012-06-14)
To evaluate the cognitive effects of fesoterodine 4 and 8 mg versus placebo in healthy older adults. This was an active- and placebo-controlled, double-blind, double-dummy crossover study conducted using healthy volunteers (aged 65-85 years) with baseline Mini-Mental State Examination score
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