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164739

Sigma-Aldrich

(+)-S-三苯甲基-L-半胱氨酸

97%, for peptide synthesis

别名:

S-三苯甲基-L-半胱氨酸

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About This Item

线性分子式:
(C6H5)3CSCH2CH(NH2)CO2H
CAS号:
2799-07-7
分子量:
363.47
Beilstein:
2339626
MDL编号:
MFCD00002611
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
24850097
NACRES:
NA.22

产品名称

(+)-S-三苯甲基-L-半胱氨酸, 97%

质量水平

100

方案

97%

旋光性

[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl

反应适用性

reaction type: solution phase peptide synthesis

mp

182-183 °C (dec.) (lit.)

应用

peptide synthesis

SMILES字符串

N[C@@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)C(O)=O

InChI

1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1

InChI key

DLMYFMLKORXJPO-FQEVSTJZSA-N

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相关类别

应用

(+)-S-三苯甲基 -L-半胱氨酸是一种非天然的含硫氨基酸，通常用作液相多肽合成（SPPS）中的溶剂。它还可用作金属结合剂，用于以 HBTU 肽偶联剂通过肽-金属相互作用合成可用于阳离子传感应用解决方案的取代的二茂铁酰肽偶联物。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCV1857
MKCP9350
MKCG2675
MKCC9351
MKBZ3032V

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James A D Good et al.
Journal of medicinal chemistry, 56(5), 1878-1893 (2013-02-12)
The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved potency, favorable drug-like properties, but
Total synthesis of didmolamides A and B
You Shu-Li and Kelly JW
Tetrahedron Letters, 46(15), 2567-2570 (2005)
Frank Kozielski et al.
Proteomics, 8(2), 289-300 (2008-01-11)
Mitotic kinesins represent potential drug targets for anticancer chemotherapy. Inhibitors of different chemical classes have been identified that target human Eg5, a kinesin responsible for the establishment of the bipolar spindle. One potent Eg5 inhibitor is S-trityl-L-cysteine (STLC), which arrests
Sébastien Brier et al.
Journal of molecular biology, 360(2), 360-376 (2006-06-20)
The mitotic kinesin Eg5 plays an essential role in establishing the bipolar spindle. Recently, several antimitotic inhibitors have been shown to share a common binding region on Eg5. Considering the importance of Eg5 as a potential drug target for cancer
Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein
Fukai R, et al.
European Journal of Medicinal Chemistry, 215, 113288-113288 (2021)
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