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Merck
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主要文件

475879

Sigma-Aldrich

莫纳托

A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.

别名:

莫纳托, 4-（3-羟基苯基）-6-甲基-2-硫代-1，2，3，4-四氢-4H-嘧啶-5-羧酸乙酯，Eg5抑制剂I

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About This Item

经验公式（希尔记法）:
C14H16N2O3S
CAS号:
254753-54-3
分子量:
292.35
MDL號碼:
MFCD00813077
分類程式碼代碼:
12352200
NACRES:
NA.32

品質等級

100

化驗

≥95% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 100 mg/mL

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

S=C1N[C@H](C(=C(N1)C)C(=O)OCC)c2cc(ccc2)O

InChI

1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)/t12-/m0/s1

InChI 密鑰

LOBCDGHHHHGHFA-LBPRGKRZSA-N

一般說明

一种有效的，可渗透细胞的，非微管蛋白相互作用的有丝分裂抑制剂。用单极纺锤体阻止哺乳动物细胞有丝分裂。在体外，它特异性抑制有丝分裂驱动蛋白Eg5的运动，Eg5是一种参与有丝分裂纺锤体组装和维持的马达蛋白（IC50=14µM）。

生化／生理作用

主要靶标
有丝分裂驱动蛋白Eg5
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：有丝分裂驱动蛋白Eg5为14µM

包裝

用惰性气体包装

警告

毒性：标准处理（A）

重構

复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。

其他說明

Kapoor，T.M.，et al. 2000.J. Cell Biol.150， 975.
Mayer，T.U.，et al. 1999.Science286, 971.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Adélaïde Allais et al.
Development (Cambridge, England), 149(13) (2022-07-01)
Preimplantation embryos often consist of a combination of euploid and aneuploid cells, suggesting that safeguards preventing the generation and propagation of aneuploid cells in somatic cells might be deficient in embryos. In somatic cells, a mitotic timer mechanism has been
Gaudeline Rémillard-Labrosse et al.
Frontiers in cell and developmental biology, 12, 1337937-1337937 (2024-03-28)
Culture of oocytes and embryos in media under oil is a cornerstone of fertility treatment, and extensively employed in experimental investigation of early mammalian development. It has been noted anecdotally by some that certain small molecule inhibitors might lose activity
Stephen DiGiuseppe et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(22), 6289-6294 (2016-05-18)
During the entry process, the human papillomavirus (HPV) capsid is trafficked to the trans-Golgi network (TGN), whereupon it enters the nucleus during mitosis. We previously demonstrated that the minor capsid protein L2 assumes a transmembranous conformation in the TGN. Here
Aleksandar I Mihajlović et al.
EMBO reports, 24(11), e57227-e57227 (2023-10-05)
Chromosome segregation errors in mammalian oocyte meiosis lead to developmentally compromised aneuploid embryos and become more common with advancing maternal age. Known contributors include age-related chromosome cohesion loss and spindle assembly checkpoint (SAC) fallibility in meiosis-I. But how effective the

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