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D7693

Sigma-Aldrich

Dynasore monohydrate

≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor

Synonyme(s) :

3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide monohydrate

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About This Item

Formule empirique (notation de Hill):
C18H14N2O4 · xH2O
Numéro CAS:
1202867-00-2
Poids moléculaire :
322.31 (anhydrous basis)
Numéro MDL:
MFCD11045288
Code UNSPSC :
12352200
ID de substance PubChem :
329798784
Nomenclature NACRES :
NA.77

product name

Dynasore monohydrate,

Forme

powder

Niveau de qualité

100

Conditions de stockage

protect from light

Couleur

off-white

Solubilité

DMSO: ≥10 mg/mL
H2O: insoluble

Température de stockage

−20°C

Chaîne SMILES 

O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O

InChI

1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;

Clé InChI

FKWZHQSDBMSHTN-ZIOFAICLSA-N

Description générale

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.

Application

Dynasore hydrate has been used:
  • for priming fetal mesenchymal stem/stromal cells (fMSC)
  • in confocal microscopy
  • in wound healing/scratch and tube-formation assay
  • to analyse its effects on Coxsackievirus A9 (CAV9) infection
  • to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
  • in live imaging of cells

Actions biochimiques/physiologiques

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogrammes

Environment
GHS09

Mention d'avertissement

Warning

Mentions de danger

H400

Conseils de prudence

P273

Classification des risques

Aquatic Acute 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Dynasore-not just a dynamin inhibitor
Preta G, et al.
Cell communication and signaling : CCS, 13(1), 24-24 (2015)
Florian Ehlgen et al.
PloS one, 7(6), e38781-e38781 (2012-06-22)
Haemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite. Two multi-spanning food vacuole membrane
Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies
Fischer E, et al
Clinical Cancer Research, clincanres-clinca0644 (2012)
Dynasore disrupts trafficking of HSV proteins
Mues MB, et al.
Journal of Virology, JVI-00636 (2015)
G J Hofmeyr et al.
BJOG : an international journal of obstetrics and gynaecology, 121(8), 951-957 (2014-03-14)
Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic logistically in
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