M0199

Mdivi-1

≥98% (HPLC), powder, mitochondrial division DRP inhibitor

• Synonyme(s) : 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone
• Formule empirique (notation de Hill): C₁₅H₁₀Cl₂N₂O₂S
• Numéro CAS: 338967-87-6
• Poids moléculaire : 353.22
• Numéro MDL: MFCD00974506
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817738
• Nomenclature NACRES : NA.77

Propriétés

• product name: Mdivi-1, ≥98% (HPLC), powder
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: >20 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
• InChI: 1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
• Clé InChI: NZJKEVWTYMOYOR-UHFFFAOYSA-N

Description

Description générale

Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.

Application

Mdivi-1 has been used:

• in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferation
• in mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)
• to induce mitochondrial damage in lung fibroblasts

Actions biochimiques/physiologiques

Mdivi-1 is a cell-permeable selective inhibitor of mitochondrial division DRP (dynamin-related GTPase) and inhibitor of the mitochondrial division dynamin (Dnm1). Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.

Caractéristiques et avantages

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable