SML1169

Pitstop 2

≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor

• Synonyme(s) : N-[5-[(4-Bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide, Pitstop-2
• Formule empirique (notation de Hill): C₂₀H₁₃BrN₂O₃S₂
• Numéro CAS: 1332879-52-3
• Poids moléculaire : 473.36
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: Pitstop 2, ≥98% (HPLC)
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to light brown
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: −20°C

Description

Application

Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis.

Actions biochimiques/physiologiques

Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion.

Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics.

Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable