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Key Documents

324410

Sigma-Aldrich

Dynasore

≥98% (HPLC), solid, dynamin inhibitor, Calbiochem®

Synonyme(s) :

Dynamin Inhibitor I, Dynasore, 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin

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About This Item

Formule empirique (notation de Hill):
C18H14N2O4
Numéro CAS:
304448-55-3
Poids moléculaire :
322.31
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

product name

Dynamin Inhibitor I, Dynasore, The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
protect from light

Couleur

pale yellow

Solubilité

DMSO: 16 mg/mL

Conditions d'expédition

ambient

Température de stockage

2-8°C

InChI

1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

Clé InChI

SYNDQCRDGGCQRZ-VXLYETTFSA-N

Description générale

A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Environmental Hazard (N)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Young, A., et al. 2009. Biochem. J., In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955.
Macia. E., et al. 2006. Dev. Cell10, 839.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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