D178454

Dimethyl phosphite

98%

• Synonyme(s) : Dimethoxyphosphine oxide, Dimethyl hydrogen phosphite, Dimethyl hydrogen phosphonate, Dimethyl phosphonate, Hydrogen dimethyl phosphite
• Formule linéaire : (CH₃O)₂P(O)H
• Numéro CAS: 868-85-9
• Poids moléculaire : 110.05
• Numéro Beilstein : 1697490
• Numéro CE : 212-783-8
• Numéro MDL: MFCD00044633
• Code UNSPSC : 12352100
• ID de substance PubChem : 24893543
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Pureté: 98%
• Forme: liquid
• Impuretés: ≤0.5% trimethyl phosphate; ≤1% methyl alcohol
• Indice de réfraction: n20/D 1.402 (lit.)
• Point d'ébullition: 170-171 °C (lit.)
• Densité: 1.2 g/mL at 25 °C (lit.)
• Chaîne SMILES: [H]P(=O)(OC)OC
• InChI: 1S/C2H7O3P/c1-4-6(3)5-2/h6H,1-2H3
• Clé InChI: HZCDANOFLILNSA-UHFFFAOYSA-N

Description

Application

Dimethyl phosphite is used in the synthesis of α-aminophosphonates, which are medicinally important phosphorus analogs of amino acids, by treating with an amine and an aldehyde or a ketone. It can also be employed in asymmetric hydrophosphonylation of aldehydes to synthesize optically active α-hydroxy phosphonates.

Dimethyl phosphite may be used as an effective alternative to organic tin hydrides as radical reducing agents for organic halides, thionoesters, and isocyanides to form the corresponding hydrocarbons. Radical translocation/cyclization reactions of terminal alkynes to form cyclic phosphonates can also be effectively carried using dimethyl phosphite as a reagent under tin-free condition.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317,H341,H351,H412
• Conseils de prudence: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Classification des risques: Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Skin Sens. 1
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 158.0 °F - closed cup
• Point d'éclair (°C): 70 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter