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S5567

Sigma-Aldrich

SP600125

≥98% (HPLC), powder or solid, JNK inhibitor

Synonyma:

1,9-Pyrazoloanthrone, Anthrapyrazolone

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen

Vybrat velikost

10 MG
2 990,00 Kč
50 MG
12 900,00 Kč

2 990,00 Kč


Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.

Vyžádat hromadnou objednávku

Vybrat velikost

Změnit zobrazení
10 MG
2 990,00 Kč
50 MG
12 900,00 Kč

About This Item

Empirický vzorec (Hillův zápis):
C14H8N2O
Číslo CAS:
Molekulová hmotnost:
220.23
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

2 990,00 Kč


Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.

Vyžádat hromadnou objednávku

Název produktu

SP600125, ≥98% (HPLC)

Quality Level

assay

≥98% (HPLC)

color

yellow

solubility

DMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow
H2O: insoluble

storage temp.

2-8°C

SMILES string

O=C1c2ccccc2-c3n[nH]c4cccc1c34

InChI

1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)

InChI key

ACPOUJIDANTYHO-UHFFFAOYSA-N

Gene Information

Application

C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis.11 It was used to treat HepG2 cells to test the effects on oxysterol-induced necrosis.12

Biochem/physiol Actions

A novel and selective inhibitor of c-Jun N-terminal kinase (JNK)
SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.10

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Molecular cytogenetics, 9, 86-86 (2016-12-08)
The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking mitosis progression and inducing cell death. Despite, all this study, the mechanism by which SP600125 inhibits mitosis-related effects in human cervical cells (HeLa cells) remains
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Targeting mGluR5 has been an attractive strategy to modulate glutamate excitotoxicity for neuroprotection. Although human clinical trials using mGluR5 negative allosteric modulators (NAMs) have included some disappointments, recent investigations have added several more attractive small molecules to this field, providing

Sortimentní položky

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

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