196870

BAY 11-7082

≥98% (HPLC), solid, NF-kB/TNF-α inhibitor, Calbiochem

• Synonyma: BAY 11-7082, (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
• Empirický vzorec (Hillův zápis): C₁₀H₉NO₂S
• Číslo CAS: 19542-67-7
• Molekulová hmotnost: 207.25
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00712162
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Vlastnosti

• Název produktu: BAY 11-7082, The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 200 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(c1ccc(cc1)C)\C=C\C#N
• InChI: 1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
• InChI key: DOEWDSDBFRHVAP-KRXBUXKQSA-N

Popis

General description

Potential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC₅₀ = 10 µM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available.

Potential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC₅₀ = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC₅₀ ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.

Biochem/physiol Actions

Target IC₅₀: 10 µM inhibiting TNF-α-inducible phosphorylation of IκBα

Cell permeable: yes

Primary Target
TNF-α-inducible phosphorylation of IκBα

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000. Hum. Pathol.31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3