Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
S4572
SANT-1
≥98% (HPLC), powder, SHH antagonist
Synonyma:
(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
Vybrat velikost
5 MG
6 350,00 Kč
25 MG
19 600,00 Kč
6 350,00 Kč
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
Vyžádat hromadnou objednávku
Vybrat velikost
Změnit zobrazení
5 MG
6 350,00 Kč
25 MG
19 600,00 Kč
About This Item
Empirický vzorec (Hillův zápis):
C23H27N5
Číslo CAS:
Molekulová hmotnost:
373.49
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
6 350,00 Kč
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
Vyžádat hromadnou objednávku
Doporučené produkty
Název produktu
SANT-1, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
Cc1nn(-c2ccccc2)c(C)c1\C=N\N3CCN(CC3)Cc4ccccc4
InChI
1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
InChI key
FOORCIAZMIWALX-JJIBRWJFSA-N
Application
- SANT-1 has been used: to treat cells and study the effect of SANT1-mediated inhibition on hedgehog signaling[1]
- in the generation of functional human pancreatic β cells in vitro[2]
- to treat of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death
Biochem/physiol Actions
SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.
SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist.
SANT-1 is known to induce apoptosis via Ras/NF-κB pathway in glioblastoma cells.[3]
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Zákazníci si také prohlíželi
Felicia W Pagliuca et al.
Cell, 159(2), 428-439 (2014-10-11)
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide an unprecedented cell source for drug discovery and cell transplantation therapy in diabetes. However, insulin-producing cells previously generated from human pluripotent stem cells (hPSC) lack many
Deobrat Dixit et al.
Cancer letters, 336(2), 347-358 (2013-04-04)
Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade
Bushra Memon et al.
Stem cell research & therapy, 9(1), 15-15 (2018-01-25)
Pancreatic progenitors (PPs) co-expressing the two transcription factors (TFs) PDX1 and NKX6.1 are recognized as the indispensable precursors of functional pancreatic β cells. Here, we aimed to establish an efficient protocol for maximizing generation of PDX1 In order to enhance
Shuhei Konagaya et al.
Scientific reports, 9(1), 640-640 (2019-01-27)
Large numbers of hormone-releasing cells, approximately 109 endocrine cells, are required to treat type I diabetes patients by cell transplantation. The SOX9-positive pancreatic epithelium proliferates extensively during the early stages of pancreatic development. SOX9-positive pancreatic epithelium is thought to be
Sigrid Nachtergaele et al.
eLife, 2, e01340-e01340 (2013-10-31)
The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate
Sortimentní položky
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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