1674004

Tretinoin

United States Pharmacopeia (USP) Reference Standard

• Synonyma: Retinoic acid, ATRA, Tretinoin, Vitamin A acid, all-trans-Retinoic acid
• Empirický vzorec (Hillův zápis): C₂₀H₂₈O₂
• Číslo CAS: 302-79-4
• Molekulová hmotnost: 300.44
• Beilstein/REAXYS Number: 2057223
• MDL number: MFCD00001551
• UNSPSC Code: 41116107
• PubChem Substance ID: 329751371
• NACRES: NA.24

Vlastnosti

• grade: pharmaceutical primary standard
• API family: tretinoin
• manufacturer/tradename: USP
• mp: 180-181 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• InChI key: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• Gene Information: human ... RARA(5914) , RARB(5915) , RARG(5916)

Popis

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Tretinoin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Tretinoin Cream
• Tretinoin Gel
• Tretinoin Topical Solution
• Isotretinoin
• Isotretinoin Capsules
• Acitretin

Biochem/physiol Actions

all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Bezpečnostní informace

• pictograms: GHS08,GHS07,GHS09
• signalword: Danger
• hcodes: H302,H315,H360FD,H410
• pcodes: P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable