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Key Documents

E9502

Sigma-Aldrich

EPPS

≥99.5% (titration)

Synonyma:

4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid, 4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid), HEPPS

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen


About This Item

Empirický vzorec (Hillův zápis):
C9H20N2O4S
Číslo CAS:
Molekulová hmotnost:
252.33
Beilstein/REAXYS Number:
3957385
EC Number:
MDL number:
UNSPSC Code:
12161700
PubChem Substance ID:
NACRES:
NA.25

Quality Level

assay

≥99.5% (titration)

form

powder

pH

7.3-8.7

useful pH range

7.3-8.7

pKa (25 °C)

8.0

pKa 

8

mp

237-239 °C (lit.)

solubility

H2O: 25 g + 50 mL, clear, colorless

λmax

A290 at ≤0.1 (C=33% w/w)

application(s)

diagnostic assay manufacturing

SMILES string

OCCN1CCN(CCCS(O)(=O)=O)CC1

InChI

1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)

InChI key

OWXMKDGYPWMGEB-UHFFFAOYSA-N

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Application

EPPS has been used:
  • to verify the effect of pH variation on the proteolytic activity of the posterior midgut (PMG) contents and anterior midgut (AMG) tissue homogenate
  • to prepare a destaining buffer to destain intensely stained gel pieces
  • to prepare digestion buffer for in-gel enzymatic digestion
  • to reconstitute the digested peptides for the processing of brain-derived extracellular vesicle (EV) proteins and 16-plex isobaric tandem mass tag (TMT) peptide labeling

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Osvědčení o analýze (COA)

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CHES ≥99.0% (titration)

Sigma-Aldrich

C2885

CHES

HEPES ≥99.5% (titration)

Sigma-Aldrich

H3375

HEPES

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Journal of industrial microbiology & biotechnology, 46(8), 1167-1178 (2019-06-09)
Recombinant monoclonal antibodies are predominantly produced in mammalian cell culture bioprocesses. Post-translational modifications affect the micro-heterogeneity of the product and thereby influence important quality attributes, such as stability, solubility, pharmacodynamics and pharmacokinetics. The analysis of the surface charge distribution of
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Science advances, 5(4), eaav1388-eaav1388 (2019-04-20)
Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD
Amir Ata Saei et al.
Nature communications, 10(1), 5715-5715 (2019-12-18)
Deconvolution of targets and action mechanisms of anticancer compounds is fundamental in drug development. Here, we report on ProTargetMiner as a publicly available expandable proteome signature library of anticancer molecules in cancer cell lines. Based on 287 A549 adenocarcinoma proteomes
Yang You et al.
Journal of extracellular vesicles, 11(1), e12183-e12183 (2022-01-15)
In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression. We have investigated the proteomic profiles of EVs that were isolated from four different human-induced pluripotent stem cell-derived neural cell types (excitatory neurons, astrocytes
Bianca Santos Henriques et al.
Frontiers in physiology, 11, 509310-509310 (2021-02-02)
Rhodnius prolixus is one important vector for the parasite Trypanosoma cruzi in Latin America, where Chagas disease is a significant health issue. Although R. prolixus is a model for investigations of vector-parasite interaction and transmission, not much has been done

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