A1651

Adenosine 3′-phosphate 5′-phosphosulfate lithium salt hydrate

≥60%, powder

• Synonyma: 3′-Phosphoadenosine 5′-phosphosulfate lithium salt, APPS, Active sulfate, PAPS
• Empirický vzorec (Hillův zápis): C₁₀H₁₅N₅O₁₃P₂S · xLi⁺ · yH₂O
• Číslo CAS: 109434-21-1
• Molekulová hmotnost: 507.26 (free acid basis)
• MDL number: MFCD00150841
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• NACRES: NA.51
• Beilstein/REAXYS Number: 8181191

Vlastnosti

• Název produktu: Adenosine 3′-phosphate 5′-phosphosulfate lithium salt hydrate, ≥60%
• form: powder
• Quality Segment: 200
• concentration: ≥60%
• shipped in: dry ice
• storage temp.: −70°C
• SMILES string: [Li+].[Li+].[Li+].[Li+].[P](=O)([O-])([O-])O[C@@H]1[C@H](O[C@H]([C@@H]1O)[n]2c3ncnc(c3nc2)N)CO[P](=O)([O-])O[S](=O)(=O)[O-].O
• InChI: 1S/C10H15N5O13P2S.4Li.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24;;;;;/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24);;;;;1H2/q;4*+1;/p-4/t4-,6-,7-,10-;;;;;/m1...../s1
• InChI key: UGODCLHJOJPPHP-AZGWGOJFSA-J

Popis

Application

3′-Phosphoadenosine 5′-phosphosulfate (PAPS) is used as a universal sulfonate donor for in vivo sulfonation by sulfotransferases. PAPS is used for the sulfation of glycans. PAPS is also useful to study the distribution and function of its biological transporter(s).

Adenosine 3′-phosphate 5′-phosphosulfate lithium salt has been used in a study that cloned and characterized a mammalian lithium-sensitive bisphosphate 3′-nucleotidase inhibited by inositol 1,4-bisphosphate. Adenosine 3′-phosphate 5′-phosphosulfate lithium salt has also been used in a study to assess the golgi-resident PAP-specific 3′-phosphatase-coupled sulfotransferase assays.

Analysis Note

Major impurities appear to be adenosine 3′,5′-diphosphate, sulfate and ammonia substitution products.

Disclaimer

Rapid decomposition occurs when exposed to room temperature: up to 17% per day at 37 °C. We ship on dry ice to minimize decomposition in transit.

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Skladovací třída: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves