A6419

Adenosine 5′-triphosphate disodium salt hydrate

microbial, BioReagent, suitable for cell culture, ≥99% (HPLC)

• Synonyma: ATP disodium salt
• Empirický vzorec (Hillův zápis): C₁₀H₁₄N₅Na₂O₁₃P₃ · xH₂O
• Číslo CAS: 34369-07-8
• Molekulová hmotnost: 551.14 (anhydrous basis)
• MDL number: MFCD00150755
• UNSPSC Code: 12352207
• eCl@ss: 32160414
• PubChem Substance ID: 24891086
• NACRES: NA.75

Vlastnosti

• biological source: microbial
• Quality Level: 200
• product line: BioReagent
• assay: ≥99% (HPLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C
• SMILES string: O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
• InChI key: NTBQNWBHIXNPRU-MSQVLRTGSA-L

Popis

General description

Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems. They are released from cells under stress and play a key role in immune response. ATP release from injured neurons and consequent breakdown leads to generation of adenosine. ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain. Elevated ATP levels are indicative of cell damage and inflammation.

Application

Adenosine 5′-triphosphate disodium salt hydrate has been used:

• as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites
• in inflammasome activation assays in bone marrow derived macrophages
• for the stimulation of macrophages
• in nucleotide synthesis

Biochem/physiol Actions

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

P₂ purinocepter agonist.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type N95 (US)