282200

Galangin

autophagy inducing flavonoid

• Synonyma: 3,5,7-Trihydroxyflavone, Norizalpinin
• Empirický vzorec (Hillův zápis): C₁₅H₁₀O₅
• Číslo CAS: 548-83-4
• Molekulová hmotnost: 270.24
• Beilstein/REAXYS Number: 272179
• EC Number: 208-960-4
• MDL number: MFCD00006833
• UNSPSC Code: 41116107
• PubChem Substance ID: 57648294
• NACRES: NA.79

Vlastnosti

• assay: ≥95% (HPLC)
• form: powder
• color: yellow
• mp: 214-215 °C (lit.)
• SMILES string: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
• InChI key: VCCRNZQBSJXYJD-UHFFFAOYSA-N
• Gene Information: human ... ADORA2A(135) , ADORA3(140) , CYP1A2(1544) ; rat ... Adora1(29290) , Adora2a(25369)

Popis

General description

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.

Application

Galangin has been used:

• as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
• to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
• as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy

Biochem/physiol Actions

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves