Y0000002
Acetylcholine chloride
European Pharmacopoeia (EP) Reference Standard
Synonyma:
ACh
Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
About This Item
Lineární vzorec:
(CH3)3N+CH2CH2OCOCH3Cl-
Číslo CAS:
Molekulová hmotnost:
181.66
Beilstein/REAXYS Number:
3571875
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Doporučené produkty
grade
pharmaceutical primary standard
API family
acetylcholine
manufacturer/tradename
EDQM
mp
146-150 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
−20°C
SMILES string
[Cl-].CC(=O)OCC[N+](C)(C)C
InChI
1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChI key
JUGOREOARAHOCO-UHFFFAOYSA-M
Gene Information
human ... CHRM3(1131)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Acetylcholine chloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
related product
Č. produktu
Popis
Stanovení ceny
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Osvědčení o analýze (COA)
Lot/Batch Number
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Zákazníci si také prohlíželi
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American journal of physiology. Gastrointestinal and liver physiology, 307(1), G77-G88 (2014-05-17)
It has been shown, in animal models, that gastrointestinal tract (GIT) motility is influenced by temperature; nevertheless, the basic mechanism governing thermal GIT smooth muscle responses has not been fully investigated. Studies based on physiologically tuned mathematical models have predicted
Peter Ong et al.
Circulation, 129(17), 1723-1730 (2014-02-28)
Coronary spasm can cause myocardial ischemia and angina in patients with and those without obstructive coronary artery disease. However, provocation tests using intracoronary acetylcholine administration are rarely performed in clinical routine in the United States and Europe. Thus, we assessed
Eliane Proulx et al.
Cellular and molecular life sciences : CMLS, 71(7), 1225-1244 (2013-10-15)
Cholinergic modulation of prefrontal cortex is essential for attention. In essence, it focuses the mind on relevant, transient stimuli in support of goal-directed behavior. The excitation of prefrontal layer VI neurons through nicotinic acetylcholine receptors optimizes local and top-down control
Sulan Luo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4), 1842-1853 (2014-01-09)
This study was performed to discover and characterize the first potent α3β2-subtype-selective nicotinic acetylcholine receptor (nAChR) ligand. A novel α4/7-conotoxin, α-CTxLvIA, was cloned from Conus lividus. Its pharmacological profile at Xenopus laevis oocyte-expressed rat nAChR subtypes was determined by 2-electrode
Xiaoqun Zhang et al.
Journal of neurochemistry, 129(4), 581-590 (2014-01-31)
The GluN2 subunits that compose NMDA receptors (NMDARs) determine functional and pharmacological properties of the receptor. In the striatum, functions and potential dysfunctions of NMDARs attributed to specific GluN2 subunits have not been clearly elucidated, although NMDARs play critical roles
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