900864

4-(Bromomethyl)-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

• Synonyma: Bromo sulfonyl fluoride TMS-alkyne, Probe building block
• Empirický vzorec (Hillův zápis): C₁₂H₁₄BrFO₂SSi
• Číslo CAS: 2088828-99-1
• Molekulová hmotnost: 349.29
• UNSPSC Code: 12352200
• NACRES: NA.22

Vlastnosti

• Quality Level: 100
• assay: ≥95%
• form: powder or crystals
• availability: available only in USA
• storage temp.: −20°C
• SMILES string: O=S(C(C(C#C[Si](C)(C)C)=C1)=CC=C1CBr)(F)=O

Popis

Application

Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

• 1.Technology Spotlight: Trifunctional Probe Building Blocks
• 2.Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Bezpečnostní informace

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class: 5.2 - Organic peroxides and self-reacting hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable