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282413

Sigma-Aldrich

2,3-Dimercapto-1-propanol tributyrate

97%

Synonyma:

BAL tributyrate

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
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About This Item

Lineární vzorec:
CH3CH2CH2CO2CH2CH(SCOCH2CH2CH3)CH2SCOCH2CH2CH3
Číslo CAS:
58428-97-0
Molekulová hmotnost:
334.49
MDL number:
MFCD00010601
UNSPSC Code:
12352100
PubChem Substance ID:
24857046
NACRES:
NA.22

assay

97%

form

liquid

refractive index

n20/D 1.495 (lit.)

bp

156-160 °C/0.15 mmHg (lit.)

density

1.083 g/mL at 25 °C (lit.)

SMILES string

CCCC(=O)OCC(CSC(=O)CCC)SC(=O)CCC

InChI

1S/C15H26O4S2/c1-4-7-13(16)19-10-12(21-15(18)9-6-3)11-20-14(17)8-5-2/h12H,4-11H2,1-3H3

InChI key

NHBKXEKEPDILRR-UHFFFAOYSA-N

Související kategorie

Application

2,3-Dimercapto-1-propanol tributyrate is a thioester analog of triacylglycerol and has been used:
  • in lipase inhibition assay during in vitro screening of medicinal plants as antidiabetics with glucosidase and lipase inhibitory activities
  • in colorimetric microplate assay for lipase activity
  • to analyze positional specificity of LipG (lipase-encoding gene) toward triacylglycerol by a simple continuous spectrophotometric method

Pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Osvědčení o analýze (COA)

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Sigma-Aldrich

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W Rick et al.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 20(8), 537-552 (1982-08-01)
The two point test for the determination of lipase by Kurooka et al. (J. Biochem. Tokyo 81, 361-369 (1977)) was studied in detail. This procedure uses 2,3-dimercapto-1-propanol-tributyrate as substrate and Ellman's reagent as an acceptor for the released thiol groups.
R N Farias et al.
Analytical biochemistry, 252(1), 186-189 (1997-11-05)
Using commercially available thiosubstrates, such as 2,3-dimercapto-1-propanol tributyrate, the regio-specificities of 1,3-specific and nonspecific lipases was confirmed. The spectrophotometric test is a simple, rapid, and convenient alternative method to those previously reported for the characterization of the positional specificities of
Guillermo Ramírez et al.
Evidence-based complementary and alternative medicine : eCAM, 2012, 701261-701261 (2012-10-20)
This work shows the inhibitory effect on glucosidase and lipase enzymes of 23 medicinal plants described as traditional treatments for diabetes in several Mexican sources. Hydroalcoholic extracts of selected plants were evaluated at 1 mg/mL for glucosidase and 0.25 mg/mL for lipase
Shota Kajiwara et al.
Journal of biotechnology, 296, 1-6 (2019-03-12)
In this study, a commercial lipase derived from Candida cylindracea was chemically modified with dextran by conjugating ε-amine in the lysine residue with the carbonyl residue in oxidized dextran using the borane-pyridine complex as a reducing agent to increase the
Suk-Jung Choi et al.
Journal of biochemistry and molecular biology, 36(4), 417-420 (2003-08-05)
The present work describes a colorimetric microplate assay for lipase activity based on the reaction between 5,5'-dithiobis(2-nitro benzoic acid) (DTNB) and the hydrolysis product of 2,3-dimercapto-1-propanol tributyrate (DMPTB). Reaction mixtures containing DTNB, DMPTB, and lipase were prepared in microplate wells
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