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64046

Sigma-Aldrich

2,3-Dimercapto-1-propanol

≥98% (iodometric)

Synonyma:

BAL, British anti-Lewisite, DMP, Dimercaprol, Dithioglycerol

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About This Item

Lineární vzorec:
HOCH2CH(SH)CH2SH
Číslo CAS:
59-52-9
Molekulová hmotnost:
124.23
Beilstein/REAXYS Number:
1732058
EC Number:
200-433-7
MDL number:
MFCD00004864
UNSPSC Code:
12352100
PubChem Substance ID:
57651969
NACRES:
NA.22

assay

≥98% (iodometric)

refractive index

n20/D 1.572-1.574
n20/D 1.573 (lit.)

bp

120 °C/15 mmHg (lit.)

density

1.239 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

OCC(S)CS

InChI

1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2

InChI key

WQABCVAJNWAXTE-UHFFFAOYSA-N

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General description

Dimercapto-1-propanol acts as a chelating agent and forms stable complexes with certain heavy metals, including arsenic, mercury, and lead.

Application

2,3-Dimercapto-1-propanol has been used in synthesizing novel (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives, which are potent tyrosinase inhibitors. It can also be considered for developing new drugs against AIDS due to its ability to inhibit HIV-1 tat activity.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

233.6 °F - closed cup

flash_point_c

112 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Osvědčení o analýze (COA)

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Sigma-Aldrich

M4007

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3-Mercapto-1-propanol 95%

Sigma-Aldrich

405736

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1-Thioglycerol ≥99.0% (GC)

Sigma-Aldrich

88640

1-Thioglycerol

1-Thioglycerol BioXtra, ≥97%

Sigma-Aldrich

M2172

1-Thioglycerol

S Kubota et al.
AIDS research and human retroviruses, 6(7), 919-927 (1990-07-01)
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional
Metal chelators and neurotoxicity: lead, mercury, and arsenic
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(5), 713-720 (2014-11-22)
Strict definition of invasive aspergillosis (IA) cases is required to allow precise conclusions about the efficacy of antifungal therapy. The Global Comparative Aspergillus Study (GCAS) compared voriconazole to amphotericin B (AmB) deoxycholate for the primary therapy of IA. Because predefined
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Lymphocytic airway inflammation is a major risk factor for chronic lung allograft dysfunction, for which there is no established treatment. We investigated whether azithromycin could control lymphocytic airway inflammation and improve allograft function. Fifteen lung transplant recipients demonstrating acute allograft
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