T7572
Trombina from human plasma
400-1000 NIH units/mg protein
Sinónimos:
Factor IIa
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About This Item
Productos recomendados
Formulario
lyophilized powder
Nivel de calidad
actividad específica
400-1000 NIH units/mg protein
impurezas
HIV, hepatitis B and hepatitis C, tested negative
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... F2(2147)
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Descripción general
Lyophilized powder containing sucrose, sodium chloride and Tris.
Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects.
Aplicación
Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess an innovative flow cytometric approach for small-size platelet microparticles.
Acciones bioquímicas o fisiológicas
Serín proteasa que hidroliza selectivamente los enlaces Arg-Gly en el fibrinógeno para formar fibrina y fibrinopéptidos A y B.
Definición de unidad
Activity is expressed in NIH units obtained by direct comparison to a NIH Thrombin Reference Standard
Nota de análisis
The NIH assay procedure uses 0.2 ml diluted plasma (1:1 with saline) as a substrate and 0.1ml of thrombin sample (stabilized in a 1% buffered albumin solution) based on a modification of the method of Biggs. Only clotting times in the range of 15-25 seconds are used for determining thrombin concentrations.
Otras notas
View more information on thrombin at www.sigma-aldrich.com/enzymeexplorer.
Cláusula de descargo de responsabilidad
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Artículos
Thrombin Factor IIa is an endolytic serine protease that selectively cleaves the Arg--Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
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