M7898
Monoclonal Anti-Thy 1.1 antibody produced in mouse
clone TN-26, purified immunoglobulin, buffered aqueous solution
Sinónimos:
Anti-CD90, Anti-CDw90
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Productos recomendados
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
TN-26, monoclonal
form
buffered aqueous solution
species reactivity
mouse
technique(s)
complement-mediated cytotoxicity assay: suitable
indirect immunofluorescence: suitable
isotype
IgM
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Thy1(21838)
General description
Monoclonal Anti-Thy 1.1 (mouse IgM isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Thymus cell antigen 1 (Thy 1.1) is a glycosylphosphatidyl-anchored protein. It belongs to the of the immunoglobulin superfamily. Thy 1.1 is expressed in stem cells, T-cells and neurons.
Specificity
Recognizes Thy 1.1 bearing cells and is less than 5% cross-reactive with Thy 1.2 bearing cells. Titer is 1:20,000 as determined by in vitro cytotoxicity against AKR/J thymocytes.
Immunogen
thymocytes from AKR/J (Thy 1.1) mice.
Application
Monoclonal Anti-Thy 1.1 antibody produced in mouse has been used in immunopanning and immunofluorescence.
Biochem/physiol Actions
Studies have shown that mice lacking the protein thymus cell antigen 1 (Thy 1.1) have an increased number of fibroblasts. It suppresses proliferation and enhances apoptosis in dermal fibroblasts, thereby modulating cell growth. This is carried out by regulating the action of β3 integrin.
Physical form
Solution in 0.1 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
¿No encuentra el producto adecuado?
Pruebe nuestro Herramienta de selección de productos.
Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Yunsong Zhang et al.
Journal of molecular neuroscience : MN, 72(6), 1402-1412 (2022-05-17)
Cellular metabolism is essentially linked to tissue remodeling and organ regeneration. MOGS, a gene that encodes cellular metabolism-related protein mannosyl-oligosaccharide glucosidase, was found to be upregulated in nerve segments after peripheral nerve injury. Bioinformatic analyses identified upstream regulators of MOGS
Dongren Yang et al.
The Journal of cell biology, 168(4), 655-666 (2005-02-09)
Schwann cells form basal laminae (BLs) containing laminin-2 (Ln-2; heterotrimer alpha2beta1gamma1) and Ln-8 (alpha4beta1gamma1). Loss of Ln-2 in humans and mice carrying alpha2-chain mutations prevents developing Schwann cells from fully defasciculating axons, resulting in partial amyelination. The principal pathogenic mechanism
Rapidly purified ganglion cells from neonatal mouse retinas allow studies of mitochondrial morphology and autophagy.
Zaninello M and Scorrano L
Pharmacological Research, 138, 16-24 (2018)
Yannick Poitelon et al.
Methods in molecular biology (Clifton, N.J.), 1739, 233-253 (2018-03-17)
In the peripheral nervous system, axons dictate the differentiation state of Schwann cells. Most of this axonal influence on Schwann cells is due to juxtacrine interactions between axonal transmembrane molecules (e.g., the neuregulin growth factor) and receptors on the Schwann
Zhenghui Cheng et al.
BMC molecular and cell biology, 22(1), 21-21 (2021-04-09)
Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, SCs de-differentiate and reprogram to gain the
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico