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X4875

Xanthine Oxidase from bovine milk

Name: Xanthine Oxidase from bovine milk
Brand: SIGMA
Price: 69.6 CHF

Grade IV, ammonium sulfate suspension, ≥0.1 units/mg protein

Sinonimo/i:

XOD, Xanthine:oxygen oxidoreductase

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Cambia visualizzazione

A voi/SKU	Disponibilità	Prezzo
10 units	Per conoscere la disponibilità, visualizza il carrello	CHF 69.60
40 units	Per conoscere la disponibilità, visualizza il carrello	CHF 207.00
120 units	Per conoscere la disponibilità, visualizza il carrello	CHF 501.00

Informazioni su questo articolo

Numero CAS:

9002-17-9

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

232-657-6

MDL number:

MFCD00082145

Numero CE:

1.17.3.2.

Specific activity:

≥0.1 units/mg protein

Biological source:

bovine milk

CHF 69.60

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Proprietà

biological source

bovine milk

Quality Segment

200

type

Grade IV

form

ammonium sulfate suspension

specific activity

≥0.1 units/mg protein

storage temp.

2-8°C

Descrizione

General description

Research area: Cell CycleXanthineoxidase (XO) is a homodimer. It is made up of two sub-units each made up of onemolybdenum and two iron-sulphur (2Fe-2S) centers.

Formerly E.C. 1.1.3.22

Application

Xanthine Oxidase from bovine milk has been used in superoxide dismutaseactivity assay.[1]Xanthine oxidase may be suitable for producing amperometric biosensors and designing-flavonoid-type inhibitors against XO for treating inflammatory diseases, gout, and hyperuricemia. It may also be used in the synthesis of superoxide because of aldehyde oxidation.

Biochem/physiol Actions

Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.

Although xanthine oxidase is found widely distributed in multiple tissues, it is highly expressed in endothelial and epithelial cells. Its expression was also increased in infected tissues where it was shown to have an anti-microbial effect due to its ability to generate reactive oxygen species. [2]Xanthineoxidase plays an important role in catalyzing the hydroxylation ofhypoxanthine to Xanthine. Later, xanthine is converted to uric acid isexcreted by the kidneys.

Physical form

Suspension in 2.3 M (NH₄)₂SO₄ containing 1 mM sodium salicylate

Analysis Note

Protein determined by biuret

Other Notes

One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.

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Questo articolo	X4376	X4500	10110434001
Sigma-Aldrich X4875 Xanthine Oxidase from bovine milk	Sigma-Aldrich X4376 Xanthine Oxidase from bovine milk	Sigma-Aldrich X4500 Xanthine Oxidase from bovine milk	Roche 10110434001 Xanthine Oxidase (XOD)
description Grade IV, ammonium sulfate suspension, ≥0.1 units/mg protein	description lyophilized powder, 0.4-1.0 units/mg protein	description Grade III, ammonium sulfate suspension, ≥0.8 units/mg protein	description from cow milk
specific activity ≥0.1 units/mg protein	specific activity 0.4-1.0 units/mg protein	specific activity ≥0.8 units/mg protein	specific activity ~1 units/mg protein (At 25 °C with xanthine as the substrate.)
biological source bovine milk	biological source bovine milk	biological source bovine milk	biological source bovine milk
form ammonium sulfate suspension	form lyophilized powder	form ammonium sulfate suspension	form suspension
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
Quality Level 200	Quality Level 300	Quality Level 200	Quality Level -
type Grade IV	type -	type Grade III	type -

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pictograms

GHS08

signalword

Danger

hcodes

H334

pcodes

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number

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Questions

2 years ago

Hello, Is there a way to find out how much 2.3M (NH4)2SO4 was used to suspend 10 Units of Xanthine Oxidase? Specifically, what is the ratio of units Xanthine Oxidase (or mg) to volume needed to create this suspension using lyophilized powder? Thank you!

1 answer
1. Technical Support
  
  2 years ago
  
  The volume of a given package size varies from lot to lot. The minimum activity of this product is 0.1 units per milligram of protein. The minimum protein concentration is 5.0 mg/mL. As an example, a lot reporting an activity of 0.3 units per milligram protein at a concentration of 13.8 mg protein per milliliter, will have a volume of 2.3 mL for the 10 Unit package size. This is determined by using the following calculation:
  10U / (0.3U/mg) = 30mg / (13.8mg/ml) = 2.3 ml volume
  The lot-specific volume may be determined by data provided in the Certificate of Analysis. Please see the link below to review a sample or lot-specific Certificate:
  https://www.sigmaaldrich.com/product/sigma/x4875#product-documentation
  
  Helpful?

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Documenti fondamentali

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Xanthine Oxidase from bovine milk

Grade IV, ammonium sulfate suspension, ≥0.1 units/mg protein

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Informazioni su questo articolo

CHF 69.60

biological source

Quality Segment

type

form

specific activity

storage temp.

General description

Application

Biochem/physiol Actions

Physical form

Analysis Note

Other Notes

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pictograms

signalword

hcodes

pcodes

Hazard Classifications

Classe di stoccaggio

wgk

flash_point_f

flash_point_c

ppe

Documentazione

Certificati d'analisi (COA)

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Questions

Hello, Is there a way to find out how much 2.3M (NH4)2SO4 was used to suspend 10 Units of Xanthine Oxidase? Specifically, what is the ratio of units Xanthine Oxidase (or mg) to volume needed to create this suspension using lyophilized powder? Thank you!

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Xanthine Oxidase from bovine milk

Grade IV, ammonium sulfate suspension, ≥0.1 units/mg protein

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Informazioni su questo articolo

X4875-10UN

CHF 69.60

biological source

Quality Segment

type

form

specific activity

storage temp.

General description

Application

Biochem/physiol Actions

Physical form

Analysis Note

Other Notes

Confronta articoli simili

Questo articolo

Still not finding the right product?

Informazioni sulla sicurezza

pictograms

signalword

hcodes

pcodes

Hazard Classifications

Classe di stoccaggio

wgk

flash_point_f

flash_point_c

ppe

Documentazione

Certificati d'analisi (COA)

Possiedi già questo prodotto?

Questions

Greg

Hello, Is there a way to find out how much 2.3M (NH4)2SO4 was used to suspend 10 Units of Xanthine Oxidase? Specifically, what is the ratio of units Xanthine Oxidase (or mg) to volume needed to create this suspension using lyophilized powder? Thank you!

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