P6532

Prostaglandin E₂

γ-irradiated, powder, BioXtra, suitable for cell culture

• Sinonimo/i: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, Dinoprostone, PGE₂
• Formula empirica (notazione di Hill): C₂₀H₃₂O₅
• Numero CAS: 363-24-6
• Peso molecolare: 352.47
• Beilstein: 4709356
• Numero CE: 206-656-6
• Numero MDL: MFCD00077861
• Codice UNSPSC: 12352209
• eCl@ss: 42020658
• ID PubChem: 24898775
• NACRES: NA.77
• Origine biologica: synthetic (organic)
• Stato: powder

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Sterilità: γ-irradiated
• Nome Commerciale: BioXtra
• Stato: powder
• Potenza: 0.25-100 ng/mL
• tecniche: cell culture | mammalian: suitable
• Solubilità: ethanol: 1 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O
• InChI: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1; XEYBRNLFEZDVAW-ARSRFYASSA-N
• Informazioni sul gene: human ... PTGER1(5731) , PTGER2(5732) , PTGER3(5733) , PTGER4(5734) , PTGIR(5739) ; mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

Descrizione

Applicazioni

For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.

Prostaglandin E2 has been used to determine its effects on collagen gel contraction mediated by alveolar cell carcinoma cell line A549.[1]

Azioni biochim/fisiol

Most biologically active prostaglandin.

Most biologically active prostaglandin. PGE₂ induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE₂-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE₂ on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.

Stato fisico

powder -20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H360FD
• Consigli di prudenza: P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges