P2645
Protein Kinase A Catalytic Subunit from bovine heart
≥9 units/μg protein (cyclic-AMP is not required for this activity), lyophilized (white powder to sticky mass to hard pellet)
Sinonimo/i:
PKA
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About This Item
Numero MDL:
Codice UNSPSC:
12352204
eCl@ss:
32160410
NACRES:
NA.32
Prezzi e disponibilità al momento non sono disponibili
Prodotti consigliati
Stato
lyophilized (white powder to sticky mass to hard pellet)
Livello qualitativo
Attività specifica
≥9 units/μg protein (cyclic-AMP is not required for this activity)
PM
40,862 Da
Temperatura di conservazione
−20°C
Descrizione generale
Applicazioni
Protein Kinase A (PKA) Catalytic Subunit from bovine heart has been used-
Azioni biochim/fisiol
Protein Kinase A (PKA) controls the transduction of Hedgehog signaling and participates in proliferation and fate specification.[7] It phosphorylates several neurotransmitter receptors, transcription factors and constituents of various intracellular signaling pathways.[8]
Protein Kinase A catalyzes the transfer of terminal phosphate from ATP to threonine or serine residues present on various proteins. This protein is inactive in the absence of cAMP, where the catalytic and regulatory subunits are bound together. The regulatory subunit, in the presence of cAMP, binds to cAMP and releases the catalytic subunit.[9]
Confezionamento
Package size based on phosphorylating units
Definizione di unità
Phosphorylating Activity: One unit will transfer 1.0 picomole phosphate from ATP to hydrolyzed and partially dephosphorylated casein per minute at pH 6.5 at 30°C, determined by measuring the production of ADP.
Stato fisico
Lyophilized powder with sucrose and phosphate buffer salts as stabilizer.
Nota sulla preparazione
Prepared from protein kinase A (P 5511)
Esclusione di responsabilità
Please note that the pack size has been changed to align with the unit definition, while the number of phosphorylating units remain the same as before.
Inibitore
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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I clienti hanno visto anche
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Vitamins & Hormones, 88, 273-291 (2012)
J A Byun et al.
Science advances, 6(25), eabb1250-eabb1250 (2020-07-01)
The functional response of a signaling system to an allosteric stimulus often depends on subcellular conditions, a phenomenon known as pluripotent allostery. For example, a single allosteric modulator, Rp-cAMPS, of the prototypical protein kinase A (PKA) switches from antagonist to
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Proceedings of the National Academy of Sciences of the United States of America, 93(12), 5819-5823 (1996-06-11)
Strongly rectifying IRK-type inwardly rectifying K+ channels are involved in the control of neuronal excitability in the mammalian brain. Whole-cell patch-clamp experiments show that cloned rat IRK1 (Kir 2.1) channels, when heterologously expressed in mammalian COS-7 cells, are inhibited following
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