Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

L9776

Sigma-Aldrich

Leucine Aminopeptidase, microsomal from porcine kidney

suitable for protein sequencing, BioReagent, lyophilized powder

Sinonimo/i:

Aminopeptidase M, Aminopeptidase N, Cathepsin III, LAP, Leucinamide aminopeptidase, Leucinaminopeptidase

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Numero CAS:
9054-63-1
Classificazione EC (Enzyme Commission):
3.4.11.2 (BRENDA, IUBMB)
Numero CE:
232-942-5
Numero MDL:
MFCD00131501
Codice UNSPSC:
12352200
NACRES:
NA.26

Nome Commerciale

BioReagent

Forma fisica

lyophilized powder

Confezionamento

vial of 50 μg

Compatibilità

suitable for protein sequencing

applicazioni

metabolomics
vitamins, nutraceuticals, and natural products

Temperatura di conservazione

−20°C

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

Leucine Aminopeptidase (LAP) is a proteolytic enzyme. It is an amino acid hydrolase that catalyzes the hydrolysis of leucine residues from the amino-terminal of proteins or peptides. LAP is naturally present in the liver, kidney, lung, and serum.

Applicazioni

Leucine Aminopeptidase has been used:
  • in proteomics analysis
  • as a treatment for protein depolymerization reaction
  • to test its effect on the degradation of human recombinant IL-8

Azioni biochim/fisiol

Leucine Aminopeptidase serves as a biomarker for drug-induced liver injury because in case of liver injury, cirrhosis, hepatitis, and other disorders serum LAP activity increases. Abnormal expression of LAP results in tumor cell proliferation, angiogenesis, and invasion, so it can also serve as a cancer-related biomarker.

Definizione di unità

One unit will hydrolyze 1.0 μmole of L-leucine-p-nitroanilide to L-leucine and p-nitroaniline per min at pH 7.2 at 37 °C. (At 25 °C, approx. 40% of the activity at 37 °C is obtained.) The activity obtained using L-leucine p-nitroanilide as substrate is 2-5 times that obtained with L-leucinamide as substrate.

Inibitore

N° Catalogo
Descrizione
Determinazione del prezzo

B8385

Bestatin hydrochloride, ≥98% (HPLC)

A6671

Actinonin

A1276

Amastatin hydrochloride hydrate, ≥97% (HPLC)

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H315,H319,H334,H335

Classi di pericolo

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 5

1 of 5

L-Leucine-7-amido-4-methylcoumarin hydrochloride

Sigma-Aldrich

L2145

L-Leucine-7-amido-4-methylcoumarin hydrochloride

Cathepsin B from human liver buffered aqueous solution, ≥1,500 units/mg protein (E1%/280)

Sigma-Aldrich

C8571

Cathepsin B from human liver

Enzima di conversione dell’angiotensina ≥2.0 units/mg protein (modified Warburg-Christian)

Sigma-Aldrich

A6778

Enzima di conversione dell′angiotensina

Pronasi from Streptomyces griseus

Roche

PRON-RO

Pronasi

Proteasi Type XIV, ≥3.5 units/mg solid, powder

Sigma-Aldrich

P5147

Proteasi

Simone Giaveri et al.
Advanced materials (Deerfield Beach, Fla.), 33(44), e2104581-e2104581 (2021-09-24)
The billion tons of synthetic-polymer-based materials (i.e. plastics) produced yearly are a great challenge for humanity. Nature produces even more natural polymers, yet they are sustainable. Proteins are sequence-defined natural polymers that are constantly recycled when living systems feed. Digestion
Yong Huang et al.
Analytical chemistry, 91(13), 8085-8092 (2019-05-31)
Drug-induced liver injury (DILI) is a frequent cause of hepatic dysfunction as well as the single most frequent reason for removing approved medications from the market, and multispectral optoacoustic tomography (MSOT) is an emerging and noninvasive imaging modality for diagnosing
Fluorescent probes for detection and bioimaging of leucine aminopeptidase
Y Chen
Materials today chemistry, 15, 100216-100216 (2020)
A Kehlen et al.
European cytokine network, 12(2), 316-324 (2001-06-12)
In rheumatic joints, high concentrations of interleukin-8 (IL-8) have been measured in synovial fluid and in pannus tissue. In both locations aminopeptidase N (APN)/CD13, an exopeptidase with reported activity towards IL-8 is also present. The surprising stability of IL-8 in
Sudha Warrier et al.
Cell biology international, 36(12), 1137-1143 (2012-07-10)
Glioblastoma is one of the most common malignant tumours in adults, with an average life expectancy of less than 1 year. The high mortality of glioblastomas is attributed to its resistance to conventional chemotherapeutic agents. Numerous studies have established the
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.