D6821

Donepezil hydrochloride

≥98% (HPLC), powder, acetylcholinesterase inhibitor

• Sinonimo/i: 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, E2020
• Formula empirica (notazione di Hill): C₂₄H₂₉NO₃ · HCl
• Numero CAS: 120011-70-3
• Peso molecolare: 415.95
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798838
• NACRES: NA.77
• MDL number: MFCD00881312
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Proprietà

• Nome del prodotto: Donepezil hydrochloride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL, H₂O: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl
• InChI: 1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2
• InChI key: HLJIZAKUNCTCQX-UHFFFAOYSA-N
• Gene Information: human ... ACHE(43)

Descrizione

Application

Donepezil hydrochloride has been used in dose-response experiment to study its efficacy in ameliorating nicotine withdrawal-induced deficits in contextual conditioning in mice.[1] It has also been intraperitoneally injected into rats to study its ability to improve social behavioral deficits, repetitive behavior and hyperactivity.[2]

Biochem/physiol Actions

Donepezil monohydrochloride monohydrate is a centrally acting reversible acetylcholinesterase inhibitor.

Donepezil monohydrochloride monohydrate is a reversible acetylcholinesterase inhibitor

Donepezil hydrochloride is a piperidine containing an organic compound and a non-competitive inhibitor. It is useful in treating Alzheimer′s disease, in which dementia is a prominent symptom. Donepezil is shown to induce cognitive ability and overall body function. It has a half-life of 70 hours.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• pictograms: GHS06
• signalword: Danger
• hcodes: H300,H319
• pcodes: P264 - P270 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 2 Oral - Eye Irrit. 2
• Classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable