E8875

17β-Estradiol

≥98% (HPLC), powder, estrogenic hormone

• Sinonimo/i: 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
• Formula empirica (notazione di Hill): C₁₈H₂₄O₂
• Numero CAS: 50-28-2
• Peso molecolare: 272.38
• Beilstein: 1914275
• Numero CE: 200-023-8
• Numero MDL: MFCD00003693
• Codice UNSPSC: 12352104
• ID PubChem: 24278426
• NACRES: NA.77

Proprietà

• Nome del prodotto: β-Estradiol, ≥98%
• Origine biologica: synthetic (organic)
• Livello qualitativo: 300
• Sterilità: non-sterile
• Saggio: ≥98%
• Stato: powder
• tecniche: cell culture | mammalian: suitable
• Punto di fusione: 176-180 °C (lit.)
• Solubilità: ethanol: 50 mg/mL, clear, colorless
• Condizioni di spedizione: ambient
• Temperatura di conservazione: room temp
• Stringa SMILE: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1; VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Informazioni sul gene: human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , GPER(2852) , SERPINA6(866) ; mouse ... Esr1(13982) , Esr2(13983) , Esrra(26379) ; rat ... Afp(24177) , Ar(24208) , Esr1(24890) , Esr2(25149) , Shbg(24775)

Descrizione

Descrizione generale

β-Estradiolis a natural steroid estrogen[1] and a female sex hormone.[2] It is an essential component of the female menstrual cycle and plays an important role in the growth and maintenance of the reproductive system.[2]

Applicazioni

β-Estradiol has been used:

• for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)[3]
• as a supplement in in vitro maturation medium (IVM), which is used as a control medium[4]
• in estrogen-induction assay[5]

Azioni biochim/fisiol

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Caratteristiche e vantaggi

This compound is featured on the Acetylcholine Receptors (Nicotinic) and Nuclear Receptors (Steroids) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H351,H360FD,H362,H410
• Consigli di prudenza: P202 - P260 - P263 - P264 - P273 - P308 + P313
• Classi di pericolo: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges