This product is intended for research use only. It is not suitable for human or veterinary use. The material has not been tested for in vivo use. The end user would need to determine suitability. Solutions intended for use in animal models would require sterile filtration prior to administration.
E2257
β-Estradiol
powder, γ-irradiated, suitable for cell culture
Sinonimo/i:
1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
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1 MG
CHF 167.00
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1 MG
CHF 167.00
About This Item
Formula empirica (notazione di Hill):
C18H24O2
Numero CAS:
Peso molecolare:
272.38
Beilstein:
1914275
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.77
Origine biologica:
synthetic (organic)
Stato:
powder
Saggio:
≥98% (HPLC)
Prodotti consigliati
Origine biologica
synthetic (organic)
Livello qualitativo
Sterilità
γ-irradiated
Nome Commerciale
BioXtra
Saggio
≥98% (HPLC)
Stato
powder
tecniche
cell culture | mammalian: suitable
Punto di fusione
176-180 °C (lit.)
Solubilità
ethanol: 1 mg/mL, clear, colorless to very faintly yellow
Compatibilità
suitable for
Condizioni di spedizione
ambient
Temperatura di conservazione
room temp
Stringa SMILE
O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
VOXZDWNPVJITMN-ZBRFXRBCSA-N
Informazioni sul gene
human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , GPER(2852) , SERPINA6(866)
mouse ... Esr1(13982) , Esr2(13983) , Esrra(26379)
rat ... Afp(24177) , Ar(24208) , Esr1(24890) , Esr2(25149) , Shbg(24775)
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Descrizione generale
β-estradiol is a natural human estrogen. It is important for the growth of breast and reproductive epithelia, maturation of long bones and the development of secondary sexual characteristics.[1] Estradiol is produced by immature germ cells, spermatozoa, Leydig cells and Sertoli cells. It plays a crucial role in proliferation, regulation of ion transport and regulation of apoptosis in Sertoli cells. Estradiol regulates sperm concentration, motility and morphology.[2] β-estradiol functions as a menopausal hormone. It is implicated in replacement therapy for female hypogonadism or primary ovarian failure. Reduced levels of β-estradiol are associated with heart disease and osteoporosis.[1]
Applicazioni
β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).
Azioni biochim/fisiol
The major estrogen secreted by the premenopausal ovary.
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
Stato fisico
powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Ricostituzione
To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Certificati d'analisi (COA)
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Determination of 17 beta-estradiol in pharmaceutical preparation by UV spectrophotometry and high performance liquid chromatography methods
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The human endometrium is one of the most hormonally responsive tissues in the body and is essential for the establishment of pregnancy. This tissue can also become diseased and cause morbidity and even death. Model systems to study human endometrial
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can this type estradiol be injected intraperitoneally in rat?
1 answer-
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What is the shelf life as a powder? What is the shelf life once in solution and stored at -20 degrees C?
1 answer-
This product does not contain an expiration date. It contains a recommended retest date of three years after the quality release date. A recommended retest date is the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.
Upon resuspension, solutions can be stored frozen at -20°C for up to 3 months . It is advised to avoid repeated freeze/thaw cycles. If stored in the refrigerator (4°C), de-gassed stock solutions are stable for up to 6 months.
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