C0150
Cathepsin B from human placenta
lyophilized powder, ≥5 units/mg protein
Sinonimo/i:
Cathepsin B1
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About This Item
Numero CAS:
Numero MDL:
Codice UNSPSC:
12352204
NACRES:
NA.54
Prezzi e disponibilità al momento non sono disponibili
Prodotti consigliati
Stato
lyophilized powder
Livello qualitativo
Attività specifica
≥5 units/mg protein
PM
24.5 kDa
Composizione
Protein, ~50% Lowry
Solubilità
H2O: soluble 1.0 mg/mL, clear
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... CTSB(1508)
Descrizione generale
Applicazioni
Cathepsin B from human placenta has been used in the in vitro digestion of modified myelin oligodendrocyte glycoprotein (MOG).[3] It has also been used in determining the effect of cysteine protease inhibitors.[2]
Cathepsin B is a lysosomal cysteine proteinase which hydrolyzes proteins with a broad specificity for peptide bonds. Cathepsin B may be a useful tool in Alzheimer′s research, as it may have a role in the natural defense against the disease [4]. Cathepsin B may be used to cleave procaspase 1 and procaspase 11, and to induce apoptosis in digitonin-permeabilized cells.
Azioni biochim/fisiol
Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.
Definizione di unità
One unit will liberate 1 nanomole of 7-amino-4-methylcoumarin from Z-Arg-Arg 7-amido-4-methylcoumarin per min at pH 6.0 at 40 °C.
Stato fisico
Lyophilized powder containing phosphate buffer salts
Nota sulla preparazione
Dissolves in water at 1 mg/mL concentration, yieliding a clear solution.
Inibitore
N° Catalogo
Descrizione
Determinazione del prezzo
Substrato
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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The specificity of inhibition by 6,6'-dihydroxythiobinupharidine (DTBN) on cysteine proteases was demonstrated in this work. There were differences in the extent of inhibition, reflecting active site structural-steric and biochemical differences. Cathepsin S (IC50 = 3.2 μM) was most sensitive to
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Articoli
Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.
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