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C7268

Sigma-Aldrich

Chymostatin

powder

Sinonimo/i:

N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)

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1 MG
CHF 60.70
5 MG
CHF 155.00
25 MG
CHF 574.00
50 MG
CHF 1’100.00
100 MG
CHF 2’090.00

CHF 60.70

Spedizione prevista il12 marzo 2025

Richiedi un ordine bulk
Tutte le immagini(6)

Scegli un formato

Cambia visualizzazione
1 MG
CHF 60.70
5 MG
CHF 155.00
25 MG
CHF 574.00
50 MG
CHF 1’100.00
100 MG
CHF 2’090.00

About This Item

Numero CAS:
9076-44-2
Numero MDL:
MFCD00071059
Codice UNSPSC:
12352202
ID PubChem:
329775144
NACRES:
NA.77

CHF 60.70

Spedizione prevista il12 marzo 2025

Richiedi un ordine bulk

product name

Chymostatin, microbial

Origine biologica

microbial

Livello qualitativo

300

Forma fisica

powder

Solubilità

DMSO: 10 mM (Stock solutions stable for months at −20 °C.)

Temperatura di conservazione

−20°C

Stringa SMILE

OC(C(NC(NC(C1NC(NCC1)=N)C([F,Cl,Br,I]C)=O)=O)CC2=CC=CC=C2)=O

InChI

MRXDGVXSWIXTQL-HYHFHBMOSA-N

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Applicazioni

Chymostatin has been used in a study that determined that molecular calculations are useful for evaluating the interactions between ligands, including inhibitors and homologous enzymes, in docking models. Chymostatin has also been used in a study to investigate the norovirus protease as an attractive target for antiviral drug development.

Azioni biochim/fisiol

Inhibits the lysosomal proteinase cathepsin B, and the soluble Ca2+-activated proteinase.[1] Many young plant tissues express a chomostatin-sensitive serine protease.[2]
Chymostatin is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, B, H, and L. It weakly inhibits human leucocyte elastase. It is effective at a final concentration of 100 to 200 μg/ml (10 to 100 μM). Chymostatin is often included in protease inhibitor cocktails used with plant extracts.

Altre note

A mixture of A (major), B and C components. A: X=Leu; B: X=Val; C: X=Ile
chymostatin A MW = 607.7
chymostatin B MW = 593.7
chymostatin C MW = 607.7

Nota sulla preparazione

Solubility testing in glacial acetic acid at 10 mg/ml yields a clear solution, which is usually colorless, but can be yellow in appearance. It is reportedly also soluble in DMSO; only slightly soluble in water and short-chain alcohols; insoluble in ethyl acetate, butyl acetate, ether, hexane, and petroleum ether. Stock solutions (10 mM) can be prepared in DMSO and are stable for months at -20 °C. Stock solutions can also be made in 0.1 M HCl. Dilute solutions (10-100 μM) are only stable for several hours, due to oxidation of the terminal aldehyde.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Programmed death ligand 1 (PD-L1) is an immune checkpoint protein that suppresses cytotoxic T lymphocytes and is often overexpressed in cancers. Due to favorable clinical trial results, immune checkpoint inhibition (ICI) is part of Food and Drug Administration approved immuno-oncology
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ProAngiotensin-12 (PA12) is the most recent peptide to be identified as a functional component of the renin-angiotensin system (RAS). PA12 is reported to constrict rat coronary arteries and the aorta, dependent upon angiotensin II-converting enzyme 1 (ACE1) and chymase. The
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Intercellular washing fluids from leaves of all tested higher plant species contained a serine-type protease which efficiently cleaved the artificial fluorogenic substrate MCA-Pro-Leu-Gly-Leu-Dnp-Ala-Arg (MCA). The activity varied between the species. The classification as serine protease was based on the sensitivity
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