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C5429

Sigma-Aldrich

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride

Sinonimo/i:

Z-RR-AMC

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About This Item

Formula empirica (notazione di Hill):
C30H39N9O6
Numero CAS:
136132-67-7
Peso molecolare:
621.69
Numero MDL:
MFCD00133576
Codice UNSPSC:
12352209
ID PubChem:
24892784
NACRES:
NA.32

Stato

powder

Livello qualitativo

200

Impurezze

~4% isopropanol

Temperatura di conservazione

−20°C

Stringa SMILE

Cl.CC1=CC(=O)Oc2cc(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12

InChI

1S/C30H39N9O6.ClH/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-26(41)22(9-5-13-35-28(31)32)38-27(42)23(10-6-14-36-29(33)34)39-30(43)44-17-19-7-3-2-4-8-19;/h2-4,7-8,11-12,15-16,22-23H,5-6,9-10,13-14,17H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,31,32,35)(H4,33,34,36);1H
HLSNWWKWVKPXKI-UHFFFAOYSA-N

Informazioni sul gene

human ... CTSB(1508)
mouse ... CTSB(13030)
rat ... CTSB(64529)

Amino Acid Sequence

Z-Arg-Arg-AMC

Applicazioni

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:
  • as a cathepsin B substrate in zymography analysis of protease in feces extract.
  • in cathepsin B activity assay.
  • as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

Substrati

Fluorogenic substrate for cathepsin B.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
BCCL5191
BCCJ3382
BCCF1094
BCCD5361
BCBV9324

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Sigma-Aldrich

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Ac-Arg-Ala-Arg-AMC

Sigma-Aldrich

SCP0006

Ac-Arg-Ala-Arg-AMC

Arachidonoyl-AMC fatty acid amide hydrolase substrate

Sigma-Aldrich

A6855

Arachidonoyl-AMC

Cathepsin D Substrate

Sigma-Aldrich

SCP0109

Cathepsin D Substrate

7-Amino-4-methylcoumarin Chromophore for substrates

Sigma-Aldrich

A9891

7-Amino-4-methylcoumarin

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Miguel G Ximénez-Embún et al.
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Frontiers in physiology, 7, 53-53 (2016-03-05)
Tyrophagus putrescentiae (Schrank, 1781) is an emerging source of allergens in stored products and homes. Feces proteases are the major allergens of astigmatid mites (Acari: Acaridida). In addition, the mites are carriers of microorganisms and microbial adjuvant compounds that stimulate
High pressure effects on the activities of cathepsins B and D of mackerel and horse mackerel muscle
Fidalgo L G
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Kai S Beckwith et al.
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Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human monocytes and macrophages. A type VII secretion system (ESX-1)
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Articoli

Enzymatic Assay of Cathepsin B

Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.

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