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P3300000

Progesterone

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

4-Pregnene-3,20-dione

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About This Item

Formula empirica (notazione di Hill):
C21H30O2
Numero CAS:
57-83-0
Peso molecolare:
314.46
Beilstein:
1915950
Numero MDL:
MFCD00003658
Codice UNSPSC:
41116107
ID PubChem:
329820168
NACRES:
NA.24
Prezzi e disponibilità al momento non sono disponibili

Grado

pharmaceutical primary standard

Famiglia di API

progesterone

Produttore/marchio commerciale

EDQM

Punto di fusione

128-132 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
RJKFOVLPORLFTN-LEKSSAKUSA-N

Informazioni sul gene

human ... PGR(5241)

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Categorie correlate

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Progesterone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Azioni biochim/fisiol

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Steroid hormone produced by the corpus luteum.
Sales restrictions may apply.

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BP449

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PHR2280

Progesterone Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2563

11-Ketoprogesterone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8932

(20R)-20-Hydroxypregn-4-en-3-one, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8933

(17α)-Pregn-4-ene-3,20-dione, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8935

(20S)-20-Hydroxypregn-4-en-3-one, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8939

(20R)-3-Oxopregn-4-en-20-yl acetate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8943

(20S)-3-Oxopregn-4-en-20-yl acetate

PHR2905

Progesterone Related Compound H, pharmaceutical secondary standard, certified reference material

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H351,H360FD,H362

Classi di pericolo

Carc. 2 - Lact. - Repr. 1A

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Rudolf Kaaks et al.
International journal of cancer, 134(8), 1947-1957 (2013-10-25)
Results from prospective studies on premenopausal serum hormone levels in relation to breast cancer risk have been inconclusive, especially with regard to tumor subtypes. Using a case-control study nested within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC)
Xiaofei Sun et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(5), 2380-2389 (2014-01-29)
Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is expressed in many organs, including female reproductive organs, and is a stem cell marker in the stomach and intestinal epithelium, hair follicles, and ovarian surface epithelium. Despite ongoing studies, the definitive physiological functions
Brett E Skolnick et al.
The New England journal of medicine, 371(26), 2467-2476 (2014-12-11)
Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated the efficacy and safety of progesterone in a large, prospective, phase
Yanping Kuang et al.
Reproductive biomedicine online, 29(6), 684-691 (2014-12-03)
Previous studies have shown that existing antral follicles in the luteal phase enable ovarian stimulation. In a pilot study, the efficacy of double stimulations during the follicular and luteal phases in women with poor ovarian response was explored (defined according
Cathrin Brisken
Nature reviews. Cancer, 13(6), 385-396 (2013-05-25)
Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase
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