440205-M

LY 83583

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM).

• Sinonimo/i: LY 83583, 6-Anilino-5,8-quinolinequinone
• Formula empirica (notazione di Hill): C₁₅H₁₀N₂O₂
• Numero CAS: 91300-60-6
• Peso molecolare: 250.25
• Numero MDL: MFCD00210756
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Colore: red-purple
• Solubilità: ethanol: 3 mg/mL; acetone: soluble
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H; GXIJYWUWLNHKNW-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca²⁺ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells.

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca²⁺ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.

Azioni biochim/fisiol

Primary Target
soluble guanylate cyclase

Target IC₅₀: 2 µM against soluble guanylate cyclase

Attenzione

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Ricostituzione

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.

Altre note

Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
Pandol, S.J., et al. 1990. J. Biol. Chem.265, 12846.
Light, D.B., et al. 1989. Science 243, 383.
Mulsch, A. 1988. J. Pharmacol. Exp. Ther.247, 283.
Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable