764205

Alkyne-PEG4-maleimide

90% (HPLC)

• Sinonimo/i: Acetylene-PEG4-maleimide
• Formula empirica (notazione di Hill): C₁₈H₂₆N₂O₇
• Peso molecolare: 382.41
• Numero MDL: MFCD22380740
• Codice UNSPSC: 12352111
• ID PubChem: 329767106
• NACRES: NA.22

Proprietà

• Saggio: 90% (HPLC)
• Forma fisica: liquid
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: cross-linking reagent
• Punto di fusione: 62-67 °C
• Gruppo funzionale: alkyne; maleimide
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(N1CCC(NCCOCCOCCOCCOCC#C)=O)C=CC1=O
• InChI: 1S/C18H26N2O7/c1-2-8-24-10-12-26-14-15-27-13-11-25-9-6-19-16(21)5-7-20-17(22)3-4-18(20)23/h1,3-4H,5-15H2,(H,19,21); GHEBECZRHJXPTL-UHFFFAOYSA-N

Descrizione

Applicazioni

Alkyne-PEG4-maleimide has been used for modification of Csy containing bacterial collagens by introducing alkyne moiety to enable it for further chemical modification.

Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable