764191

Alkyne-PEG5-N-hydroxysuccinimidyl ester

• Sinonimo/i: Acetylene-PEG5-NHS ester, Alkyne-PEG5-NHS ester, Alkyne-PEG5-succinimidyl ester
• Formula empirica (notazione di Hill): C₁₈H₂₇NO₉
• Peso molecolare: 401.41
• Numero MDL: MFCD22574798
• Codice UNSPSC: 12352108
• ID PubChem: 329767105
• NACRES: NA.22

Proprietà

• Stato: liquid
• Livello qualitativo: 100
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: cross-linking reagent
• Gruppo funzionale: NHS ester; alkyne
• Temperatura di conservazione: −20°C
• Stringa SMILE: C#CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
• InChI: 1S/C18H27NO9/c1-2-6-23-8-10-25-12-14-27-15-13-26-11-9-24-7-5-18(22)28-19-16(20)3-4-17(19)21/h1H,3-15H2; ACZDUKRWTPZVRP-UHFFFAOYSA-N

Descrizione

Applicazioni

Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a primary amine. The succinimidyl ester group will react preferentially with primary amines to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification amine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable