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39468

Sigma-Aldrich

αAcide α-cyano-4-hydroxycinnamique

matrix substance for MALDI-MS, Ultra pure

Synonyme(s) :

αα-CCA, αα-CHCA, αα-Cyano, 4-HCCA, ACCA

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About This Item

Formule linéaire :
HOC6H4CH=C(CN)CO2H
Numéro CAS:
28166-41-8
Poids moléculaire :
189.17
Numéro Beilstein :
3271427
Numéro CE :
248-879-1
Numéro MDL:
MFCD00004204
Code UNSPSC :
41116105
ID de substance PubChem :
329755873
Nomenclature NACRES :
NA.21

Qualité

matrix substance for MALDI-MS

Niveau de qualité

100

Forme

solid

Classe(s) chimique(s) de l'analyte

glycans, peptides, proteins

Technique(s)

MALDI-MS: suitable

Pf

245-250 °C (lit.)
245-250 °C

Solubilité

methanol: 10 mg/mL, clear

Traces de cations

Al: ≤1 mg/kg
Ba: ≤1 mg/kg
Ca: ≤1 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤1 mg/kg
Li: ≤1 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Na: ≤1 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤1 mg/kg
Zn: ≤1 mg/kg

Température de stockage

2-8°C

Chaîne SMILES 

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

Clé InChI

AFVLVVWMAFSXCK-VMPITWQZSA-N

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Description générale

α-Cyano-4-hydroxycinnamic acid (α-CHCA) functions as matrix and helps in facilitating ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer.

Application

It was used as matrix in improving the detection of low concentration protein digests on MALDI-TOF.

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αAcide α-cyano-4-hydroxycinnamique, suitable for MALDI-TOF MS

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Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Classification des risques

Skin Sens. 1B

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificats d'analyse (COA)

Lot/Batch Number
BCCL7510
BCCK3475
BCCJ3734
BCCF7066
BCCD4901

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Consulter la Bibliothèque de documents

Xiangping Zhu et al.
Journal of biomolecular techniques : JBT, 14(4), 298-307 (2004-01-13)
Alpha-cyano-4-hydroxycinnamic acid (alpha-CHCA) as a matrix facilitates the ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer. The matrix itself also ionizes and so do its sodium and potassium adducts. Matrix clusters and metal
Mohammadreza Shariatgorji et al.
Analytical chemistry, 84(16), 7152-7157 (2012-08-07)
D(4)-α-Cyano-4-hydroxycinnamic acid (D(4)-CHCA) has been synthesized for use as a matrix for matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) and MALDI-MS imaging (MSI) of small molecule drugs and endogenous compounds. MALDI-MS analysis of small molecules has historically been hindered by interference
Kamil Karolczak et al.
International journal of pharmaceutics, 436(1-2), 508-518 (2012-06-23)
We hypothesized that BBB is impaired in rat model of streptozotocin-induced diabetes and can be sealed by poly(amido)amine dendrimers G4.0 (PAMAM G4), which reveal anti-glycation activity. The BBB permeabilization was monitored in rats with the 60-day streptozotocin-diabetes and non-diabetic animals
Rossella Gottardo et al.
Journal of mass spectrometry : JMS, 47(1), 141-146 (2012-01-28)
Since 2004, a number of herbal blends containing different synthetic compounds mimicking the pharmacological activity of cannabinoids and displaying a high toxicological potential have appeared in the market. Their availability is mainly based on the so-called "e-commerce", being sold as
Anne R Diers et al.
The Biochemical journal, 444(3), 561-571 (2012-03-31)
Recent studies have highlighted the fact that cancer cells have an altered metabolic phenotype, and this metabolic reprogramming is required to drive the biosynthesis pathways necessary for rapid replication and proliferation. Specifically, the importance of citric acid cycle-generated intermediates in
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