Direkt zum Inhalt

1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF.

1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF.

Journal of neurochemistry (1995-12-01)

Y Kotake, Y Tasaki, Y Makino, S Ohta, M Hirobe

ZUSAMMENFASSUNG

1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography-selected ion-monitoring method. The level of 1BnTIQ was very high in CSF of some parkinsonian patients compared with that of controls with other neurological diseases, the mean value being three times higher (parkinsonians: 1.17 +/- 0.35 ng/ml of CSF, n = 18; vs. controls: 0.40 +/- 0.10 ng/ml of CSF, n = 11; mean +/- SEM, not significantly different). The pole test, a toxicological examination to evaluate behavior abnormalities related to Parkinson's disease, was used to examine the pharmacological effect of 1BnTIQ in mice. Repeated administration of 1BnTIQ induced behavior abnormalities, which pretreatment with 1-methyl-1,2,3,4-tetrahydroisoquinoline could prevent. We suggest that 1BnTIQ may be related to the idiopathic Parkinson's disease.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

Sigma-Aldrich

Taurin, ≥99%

Sigma-Aldrich

Aluminium, powder, ≥91% (complexometric)

Sigma-Aldrich

Zink, dust, <10 μm, ≥98%

Sigma-Aldrich

L-Cystin, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%

Sigma-Aldrich

Magnesium, powder, ≥99%

Sigma-Aldrich

Zink, powder, <150 μm, 99.995% trace metals basis

Sigma-Aldrich

L-Cystin, ≥98% (TLC), crystalline

Sigma-Aldrich

S-(5′-Adenosyl)-L-Homocystein, crystalline

SAFC

L-Cystin

Sigma-Aldrich

Taurin, suitable for cell culture, meets USP testing specifications

Sigma-Aldrich

Kupfer, powder, 99.99% trace metals basis

Sigma-Aldrich

Zinn, ≥99%, powder

Sigma-Aldrich

Silizium, powder, −325 mesh, 99% trace metals basis

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 2800, slurry, in H₂O, active catalyst

Sigma-Aldrich

Kupfer, foil, thickness 0.25 mm, 99.98% trace metals basis

Sigma-Aldrich

Kupfer, powder, <425 μm, 99.5% trace metals basis

Sigma-Aldrich

Calcium, granular, 99%

Sigma-Aldrich

Mangan, powder, ≥99.9% trace metals basis

Sigma-Aldrich

Kupfer, wire, diam. 1.0 mm, ≥99.9%

Sigma-Aldrich

Zinn, powder, <150 μm, 99.5% trace metals basis

Sigma-Aldrich

L-Cystin, ≥99.7% (TLC)

Sigma-Aldrich

Magnesium, ribbon, ≥99.0% Mg basis

Sigma-Aldrich

Magnesium, purum, for Grignard reactions, ≥99.5%, turnings

Sigma-Aldrich

Zink, foil, thickness 0.25 mm, 99.9% trace metals basis

Sigma-Aldrich

Silizium, wafer (single side polished), <100>, N-type, contains no dopant, diam. × thickness 2 in. × 0.5 mm

Sigma-Aldrich

Aluminium, wire, diam. 1.0 mm, 99.999% trace metals basis

Sigma-Aldrich

Nickel, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis

Sigma-Aldrich

Titan, foil, thickness 0.127 mm, 99.7% trace metals basis

Sigma-Aldrich

Zink, nanopowder, 40-60 nm avg. part. size, ≥99% trace metals basis

Sigma-Aldrich

DL-Homocystein, ≥95% (titration)