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T7165

Sigma-Aldrich

Tyrphostin 23

≥98%

Synonym(e):

(3,4-Dihydroxybenzylidene)malononitrile, RG-50810

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About This Item

Empirische Formel (Hill-System):
C10H6N2O2
CAS-Nummer:
118409-57-7
Molekulargewicht:
186.17
MDL-Nummer:
MFCD00133899
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278041
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Assay

≥98%

Form

powder

Wirksamkeit

35 μM IC50

Löslichkeit

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

Lagertemp.

2-8°C

SMILES String

Oc1ccc(cc1O)\C=C(\C#N)C#N

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

InChIKey

VTJXFTPMFYAJJU-UHFFFAOYSA-N

Angaben zum Gen

human ... CDK2(1017)

Anwendung

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.

Biochem./physiol. Wirkung

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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E Heim
Zeitschrift fur Psychosomatische Medizin und Psychoanalyse, 38(3), 207-226 (1992-01-01)
Stressors and health risks in medical professions are still largely ignored. A survey on different studies in nurses, students, doctors and dentists by this author is compared to results of other authors. Special attention is given to role-strain and health
Masaru Fujimoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 6094-6099 (2010-03-17)
Endocytosis performs a wide range of functions in animals and plants. Clathrin-coated vesicle (CCV) formation is an initial step of endocytosis, and in animal cells is largely achieved by dynamins. However, little is known of its molecular mechanisms in plant
Janusz Ligęza et al.
Acta biochimica Polonica, 58(3), 391-396 (2011-09-03)
Autocrine growth factors produced by epithelial cells mediate the development and proliferation of neoplastic human prostate tissue. Various approaches have been used to down-regulate neoplastic growth of prostate cancer using natural flavonoids, soluble receptors, pseudo-ligands, monoclonal antibodies and tyrosine kinase
Sheung Kwan Lam et al.
The Plant journal : for cell and molecular biology, 60(5), 865-881 (2009-08-28)
Brefeldin A (BFA) is a useful tool for studying protein trafficking and identifying organelles in the plant secretory and endocytic pathways. At low concentrations (5-10 microg ml(-1)), BFA caused both the Golgi apparatus and trans-Golgi network (TGN), an early endosome
Mikyung Yang et al.
American journal of physiology. Lung cellular and molecular physiology, 294(5), L1007-L1012 (2008-03-18)
We assessed the roles of the protein kinase C (PKC) and the tyrosine kinase (TK) signaling pathways in regulating capacitative calcium entry (CCE) in human pulmonary artery smooth muscle cells (PASMCs) and investigated the effects of intravenous anesthetics (midazolam, propofol
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