SML0635

AZD6765 dihydrochloride

≥97% (HPLC)

• Synonym(e): (αS)-α-Phenyl-2-pyridineethanamine dihydrochloride, AR-R 15896 dihydrochloride, FPL 15896 dihydrochloride, Lanicemine dihydrochloride
• Empirische Formel (Hill-System): C₁₃H₁₄N₂ · 2HCl
• CAS-Nummer: 153322-06-6
• Molekulargewicht: 271.19
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]/D +77 to +90°, c = 1 in methanol
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [Cl-].[Cl-].[N+H3][C@@H](Cc2[n+H]cccc2)c1ccccc1
• InChI: 1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1
• InChI key: KHJHFYAGQZYCLC-GXKRWWSZSA-N

Beschreibung

Application

AZD6765 dihydrochloride has been used as an antidepressant to improve behavior and metabolic measures in chronic unpredictable mild stress (CUMS).

Biochem/physiol Actions

AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant.

AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant. In a recent study AZD6765 relieved depression within 80 minutes, unlike most antidepressants acting on serotonin or dopamine systems which can take several weeks to work. The effects lasted from about an hour up to 2 weeks. AZD6765 has an IC₅₀ value of 1.3 μM. Unlike more potent drugs such as ketamine, which also has rapid antidepressant activity, AZD6765 has no dissociative side-effects such as hallucinations. Earlier studies inidcated the compound has neuroprotective and anticonvulsant effects.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301
• Sicherheitshinweise: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable