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T5955

Sigma-Aldrich

3,4,5,6-Tetrahydroxyxanthone hydrate

≥98% (HPLC)

Synonym(e):

3,4,5,6-Tetrahydroxy-9H-xanthen-9-one hydrate, MB7

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About This Item

Empirische Formel (Hill-System):
C13H8O6 · xH2O
CAS-Nummer:
99420-08-3
Molekulargewicht:
260.20 (anhydrous basis)
MDL-Nummer:
MFCD18432705
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329826835
NACRES:
NA.77

Assay

≥98% (HPLC)

Farbe

light brown to brown

Löslichkeit

DMSO: >10 mg/mL

Lagertemp.

2-8°C

SMILES String

O.Oc1ccc2C(=O)c3ccc(O)c(O)c3Oc2c1O

InChI

1S/C13H8O6.H2O/c14-7-3-1-5-9(16)6-2-4-8(15)11(18)13(6)19-12(5)10(7)17;/h1-4,14-15,17-18H;1H2

InChIKey

ZFTTXYRPFMYDRT-UHFFFAOYSA-N

Biochem./physiol. Wirkung

3,4,5,6-Tetrahydroxyxanthone is a Na/K-ATPase inihibitor that inhibits pump function without activating the kinase signaling function. It inhibits Na/K ATPase pump action with an affinity comparable to ouabain, but does not alter Na or ATP affinity, is not blocked by potassium, and it does not activate the Src complex or downstream kinases.

Angaben zur Herstellung

3,4,5,6-Tetrahydroxyxanthone hydrate is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

P-Sätze

P301 + P310

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Orhan Aktas et al.
The Journal of experimental medicine, 197(6), 725-733 (2003-03-12)
Statins, known as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, exhibit numerous functions related to inflammation, such as MHC class II down-regulation, interference with T cell adhesion, and induction of apoptosis. Here we demonstrate that both subcutaneous and oral administration
Rodrigo Quezada et al.
Nanomaterials (Basel, Switzerland), 10(6) (2020-06-12)
Type of metal and metal-oxide NPs added to modify Thin-Film Composites Reverse Osmosis Membranes (TFC-RO) can alter their anti-biofouling properties by changing the dissolution process. The development of a mathematical model can facilitate the selection of these NPs. This work
M Armendariz Ontiveros et al.
Materials (Basel, Switzerland), 12(13) (2019-07-03)
The anti-biofouling and desalination properties of thin film composite reverse osmosis membranes (TFC-RO), modified by the incorporation of copper and iron nanoparticles, were compared. Nanoparticles of metallic copper (CuNPs) and an iron crystalline phase mix (Fe and Fe2O3, FeNPs) were

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