T5651

Tetrodotoxin with Citrate Buffer

pH 4.8, powder

• Synonym(e): Fugu poison, Maculotoxin, TTX, Tarichatoxin
• Empirische Formel (Hill-System): C₁₁H₁₇N₃O₈
• CAS-Nummer: 4368-28-9
• Molekulargewicht: 319.27
• Beilstein: 49176
• MDL-Nummer: MFCD00213719
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24900308

Eigenschaften

• Form: powder
• Verfügbarkeit: not available in USA
• pH-Wert: 4.8
• Löslichkeit: H₂O: soluble (stable at pH 4-5 if stored frozen); strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
• Lagertemp.: 2-8°C
• SMILES String: OC[C@@]1(O)[C@H]2OC3(O)OC1C4[C@@H](O)NC(=N)NC4([C@@H]2O)[C@@H]3O
• InChI: 1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1
• InChIKey: CFMYXEVWODSLAX-IXUBDLNJSA-N
• Angaben zum Gen: rat ... Scnn1g(24768)

Beschreibung

Anwendung

Tetrodotoxin has been used to study its effects on microglial functions in rats². This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway³.

Biochem./physiol. Wirkung

Reversible, selective blocker of Na⁺ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Verpackung

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Angaben zur Herstellung

The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300
• P-Sätze: P301 + P330 + P331 + P310
• Gefahreneinstufungen: Acute Tox. 1 Oral
• Lagerklassenschlüssel: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable